METTLing in Stem Cell and Cancer Biology

• Published in: Stem cell reviews and reports Vol. 19; no. 1; pp. 76 - 91
• Main Authors: Tooley, John G., Catlin, James P., Tooley, Christine E. Schaner
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2023; Springer Nature B.V
• Subjects: Animal models; Animals; Biology; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Cell Biology; Cell differentiation; Cell Differentiation - genetics; Cell self-renewal; Embryogenesis; Embryonic Stem Cells; Hematopoietic stem cells; Life Sciences; Mesenchyme; Methyltransferases - genetics; Methyltransferases - metabolism; Mice; N6-methyladenosine; Neoplasms - genetics; Neoplasms - metabolism; Neural stem cells; Nucleotides; Pluripotency; Regenerative Medicine/Tissue Engineering; RNA - metabolism; Roles; Stem Cells; Tumorigenesis; Translation; Transcription; Stem cell; Methyltransferase; METTL; Metabolism; Cancer

The methyltransferase-like (METTL) family is a diverse group of methyltransferases that can methylate nucleotides, proteins, and small molecules. Despite this diverse array of substrates, they all share a characteristic seven-beta-strand catalytic domain, and recent evidence suggests many also share...