Association of IL-12B genetic polymorphism with the susceptibility and disease severity of ankylosing spondylitis

• Published in: Journal of rheumatology Vol. 39; no. 1; p. 135
• Main Authors: Wong, Ruey-Hong, Wei, James Cheng-Chung, Huang, Chun-Huang, Lee, Hong-Shen, Chiou, Shang-Yan, Lin, Shin-Hua, Cai, Yan-Wei, Hung, Pei-Hsuan, Wang, Ming-Fuu, Yang, Shun-Fa
• Format: Journal Article
• Language: English
• Published: Canada 01.01.2012
• Subjects: Adult; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-12 Subunit p40 - genetics; Male; Middle Aged; Polymorphism, Genetic; Receptors, Interleukin - genetics; Severity of Illness Index; Spondylitis, Ankylosing - genetics; Spondylitis, Ankylosing - physiopathology

Interleukin 23 (IL-23) stimulates the differentiation of T helper 17 (Th17) cells, which are involved in the pathogenesis of ankylosing spondylitis (AS). Binding of IL-23 to the IL-23 receptor complex activates Janus kinases 2 and tyrosine kinase 2, which phosphorylate IL-23R and subsequently promot...