The in vivo and in vitro interactions of elastic and rigid vesicles with human skin

• Published in: Biochimica et biophysica acta Vol. 1573; no. 2; pp. 130 - 140
• Main Authors: Loan Honeywell-Nguyen, P, de Graaff, Anko M, Wouter Groenink, H.W, Bouwstra, Joke A
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 14.11.2002
• Subjects: Buffers; Drug Delivery Systems; Elastic vesicle; Elasticity; Freeze fracture electron microscopy; Freeze Fracturing; Humans; In Vitro Techniques; Micelles; Microscopy, Electron; Polyethylene Glycols; Polysorbates - chemistry; Skin; Skin - chemistry; Skin - drug effects; Skin - ultrastructure; Skin Physiological Phenomena; Succinates; Sucrose - analogs & derivatives; Sucrose - chemistry; Surface-Active Agents - chemistry; Surface-Active Agents - pharmacology; Tape stripping; Tape stripping; Skin; Freeze fracture electron microscopy; Elastic vesicle

Elastic vesicles are the most novel development in vesicular systems design for dermal and transdermal drug delivery. However, interactions between these vesicles and human skin are not yet fully understood. In this study, the in vivo and in vitro interactions between elastic-, rigid vesicles and mi...