PDGFRα-positive cell-derived TIMP-1 modulates adaptive immune responses to influenza A viral infection - Dutta, Saugata; Zhu, Yin; Almuntashiri, Sultan; Peh, Hong Yong; Zuñiga, Joaquin; Zhang, Duo; Somanath, Payaningal R.; Ramírez, Gustavo; Irineo-Moreno, Valeria; Jiménez-Juárez, Fabiola; López-Salinas, Karen; Regino, Nora; et al. (American journal of physiology. Lung cellular and molecular physiology, 2025)
Keywords: Adaptive Immunity; Animals; Bronchus; Clonal deletion; CXCL12 protein; Female; Growth factors; Humans; Immune response; In vivo methods and tests; Infections; Influenza; Influenza A; Influenza A Virus, H1N1 Subtype - immunology; Influenza, Human - immunology; Lavage; Leukocytes (neutrophilic); Lung - immunology; Lung - metabolism; Lung - pathology; Lung - virology; Lungs; Lymphocytes; Lymphocytes T; Macrophages; Male; Matrix metalloproteinase; Matrix metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mortality; Myofibroblasts - immunology; Myofibroblasts - metabolism; Myofibroblasts - pathology; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - virology; Pathogenesis; Physiology; Plasma levels; Receptor, Platelet-Derived Growth Factor alpha - genetics; Receptor, Platelet-Derived Growth Factor alpha - metabolism; Therapeutic targets; Tissue inhibitor of metalloproteinase 1; Tissue Inhibitor of Metalloproteinase-1 - metabolism; Transforming Growth Factor beta - metabolism; Transforming growth factor-b; Weight loss; lipofibroblast; PDGFRα; CXCL12; myofibroblast; adaptive immunity