Biological properties of Schinus terebinthifolia Raddi essential oil

Abstract Schinus terebinthifolia Raddi green fruits essential oil (EO) was evaluated regarding its phytochemical profile, antimicrobial and cytotoxic activities, and toxicity. Gas chromatography with mass spectrometry was applied to identify its constituents, thereafter the minimum inhibitory concen...

Full description

Saved in:
Bibliographic Details
Published inBrazilian Journal of Pharmaceutical Sciences Vol. 58
Main Authors Vasconcelos, Priscilla Guimarães Silva, Alves, Érika Ponchet, Maia, Carolina Medeiros de Almeida, Brito, Arella Cristina Muniz, Silva, Diego Romário, Freires, Irlan Almeida, Cavalcanti, Yuri Wanderley, Rehder, Vera Lucia Garcia, Ruiz, Ana Lúcia Tasca Gois, Duarte, Marta Cristina Teixeira, Rosalen, Pedro Luiz, Godoy, Gustavo Pina, Costa, Edja Maria Melo de Brito
Format Journal Article
LanguageEnglish
Portuguese
Published Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 01.01.2022
Universidade de São Paulo
Subjects
Anacardiaceae
Medicinal plants
PHARMACOLOGY & PHARMACY
Products with antimicrobial action
Toxicity test
Medicinal plants
Toxicity test
Products with antimicrobial action
Anacardiaceae
Online AccessGet full text

Cover

Abstract Abstract Schinus terebinthifolia Raddi green fruits essential oil (EO) was evaluated regarding its phytochemical profile, antimicrobial and cytotoxic activities, and toxicity. Gas chromatography with mass spectrometry was applied to identify its constituents, thereafter the minimum inhibitory concentration, minimum bactericidal and fungicidal concentrations, and its antibiofilm activity were evaluated. The EO cytotoxicity was assessed in tumor and non-tumor human cells, and in vivo toxicity was evaluated in a Galleria mellonella model. The major constituents of S. terebinthifolia EO were alpha-phellandrene and beta-phellandrene. The EO had a weak activity against all strains of Candida albicans (MIC 1000μg/mL) and had no activity against non-albicans strains, bacteria, and C. albicans biofilm. Cytostatic activity against all tumor cell lines was shown. Additionally, cell viability remained at EO concentrations up to 62.5 μg/mL. At 16 mg/mL, 50% hemolysis was observed, and it had low toxicity in vivo. Overall, the S. terebinthifolia EO was characterized by low antimicrobial and antibiofilm activities, with no evidence of toxicity to human tumor and non-tumor cells.
AbstractList Abstract Schinus terebinthifolia Raddi green fruits essential oil (EO) was evaluated regarding its phytochemical profile, antimicrobial and cytotoxic activities, and toxicity. Gas chromatography with mass spectrometry was applied to identify its constituents, thereafter the minimum inhibitory concentration, minimum bactericidal and fungicidal concentrations, and its antibiofilm activity were evaluated. The EO cytotoxicity was assessed in tumor and non-tumor human cells, and in vivo toxicity was evaluated in a Galleria mellonella model. The major constituents of S. terebinthifolia EO were alpha-phellandrene and beta-phellandrene. The EO had a weak activity against all strains of Candida albicans (MIC 1000μg/mL) and had no activity against non-albicans strains, bacteria, and C. albicans biofilm. Cytostatic activity against all tumor cell lines was shown. Additionally, cell viability remained at EO concentrations up to 62.5 μg/mL. At 16 mg/mL, 50% hemolysis was observed, and it had low toxicity in vivo. Overall, the S. terebinthifolia EO was characterized by low antimicrobial and antibiofilm activities, with no evidence of toxicity to human tumor and non-tumor cells.
Author Silva, Diego Romário
Godoy, Gustavo Pina
Maia, Carolina Medeiros de Almeida
Rosalen, Pedro Luiz
Ruiz, Ana Lúcia Tasca Gois
Rehder, Vera Lucia Garcia
Freires, Irlan Almeida
Cavalcanti, Yuri Wanderley
Alves, Érika Ponchet
Duarte, Marta Cristina Teixeira
Brito, Arella Cristina Muniz
Costa, Edja Maria Melo de Brito
Vasconcelos, Priscilla Guimarães Silva
AuthorAffiliation State University of Paraíba
University of Campinas
University of Florida College of Dentistry
Federal University of Paraíba
Universidade Estadual de Campinas
AuthorAffiliation_xml – name: University of Florida College of Dentistry
– name: University of Campinas
– name: State University of Paraíba
– name: Federal University of Paraíba
– name: Universidade Estadual de Campinas
Author_xml – sequence: 1
  givenname: Priscilla Guimarães Silva
  orcidid: 0000-0001-8975-7162
  surname: Vasconcelos
  fullname: Vasconcelos, Priscilla Guimarães Silva
  organization: State University of Paraíba, Brazil
– sequence: 2
  givenname: Érika Ponchet
  surname: Alves
  fullname: Alves, Érika Ponchet
  organization: State University of Paraíba, Brazil
– sequence: 3
  givenname: Carolina Medeiros de Almeida
  surname: Maia
  fullname: Maia, Carolina Medeiros de Almeida
  organization: State University of Paraíba, Brazil
– sequence: 4
  givenname: Arella Cristina Muniz
  surname: Brito
  fullname: Brito, Arella Cristina Muniz
  organization: State University of Paraíba, Brazil
– sequence: 5
  givenname: Diego Romário
  surname: Silva
  fullname: Silva, Diego Romário
  organization: University of Campinas, Brazil
– sequence: 6
  givenname: Irlan Almeida
  surname: Freires
  fullname: Freires, Irlan Almeida
  organization: University of Florida College of Dentistry, United States
– sequence: 7
  givenname: Yuri Wanderley
  orcidid: 0000-0002-3570-9904
  surname: Cavalcanti
  fullname: Cavalcanti, Yuri Wanderley
  organization: Federal University of Paraíba, Brazil
– sequence: 8
  givenname: Vera Lucia Garcia
  surname: Rehder
  fullname: Rehder, Vera Lucia Garcia
  organization: University of Campinas, Brazil
– sequence: 9
  givenname: Ana Lúcia Tasca Gois
  surname: Ruiz
  fullname: Ruiz, Ana Lúcia Tasca Gois
  organization: University of Campinas, Brazil; University of Campinas, Brazil
– sequence: 10
  givenname: Marta Cristina Teixeira
  surname: Duarte
  fullname: Duarte, Marta Cristina Teixeira
  organization: University of Campinas, Brazil
– sequence: 11
  givenname: Pedro Luiz
  surname: Rosalen
  fullname: Rosalen, Pedro Luiz
  organization: University of Campinas, Brazil
– sequence: 12
  givenname: Gustavo Pina
  surname: Godoy
  fullname: Godoy, Gustavo Pina
  organization: State University of Paraíba, Brazil
– sequence: 13
  givenname: Edja Maria Melo de Brito
  orcidid: 0000-0002-3166-709X
  surname: Costa
  fullname: Costa, Edja Maria Melo de Brito
  organization: State University of Paraíba, Brazil
BookMark eNptkd1KAzEQhYNUsNa-w_oAW5Nsfi-1_hUEwep1yGYnbcq6KckW9O3dtlK88GqGmTkfhzmXaNTFDhC6JnhGuMY3mRLJSy01ppgSjPEXBYoZkWdofFqN_vQXaJrzZjgknCnN-Bjd34XYxlVwti22KW4h9QFyEX2xdOvQ7XLRQ4I6dP06-NgGW7zZpgkF5AxdHwZVDO0VOve2zTD9rRP08fjwPn8uX16fFvPbl9JVgvQlIZhg7pRzmknuObWgmkpIAV5I7SU0jBOnhaVgK4qJstL7mlNWac699tUELY7cJtqN2abwadO3iTaYwyCmlbGDf9eC8dpqh5UG11jGa6qErIkVUoqBLJQcWLMjK7sAbTSbuEvdYN4siVbMKMr3T6X7X2EsJR0E-ihwKeacwJ8MEGz2cZhDHOafOKofMal88A
Cites_doi 10.1080/0972060X.2014.935043
10.1590/S0074-02762002000700017
10.1590/S0102-695X2011005000102
10.1038/nrd3801
10.1590/S1678-77572012000100013
10.1016/j.sajb.2016.09.005
10.1016/j.bbrc.2011.06.176
10.1007/s11095-016-2069-z
10.1016/j.indcrop.2016.03.044
10.1590/S0100-40422007000800030
10.1021/acs.jnatprod.5b01055
10.2217/fmb-2016-0099
10.1016/j.jep.2008.07.005
10.1016/j.sajb.2019.10.009
10.1371/journal.ppat.1006056
10.1016/j.foodcont.2018.07.034
10.1016/j.supflu.2017.07.006
10.1038/nrc1951
10.1590/1807-3107bor-2019.vol33.0023
10.1016/j.mib.2019.04.001
10.1111/j.1750-3841.2010.01711.x
10.1016/j.biopha.2018.01.146
10.1016/j.mib.2013.06.013
10.32712/2446-4775.2011.158
10.1590/S1516-05722013000100022
10.7717/peerj.3038
10.1093/jnci/83.11.757
10.5935/2446-4775.20180013
10.1080/00986445.2018.1515074
10.1080/01635581.2014.936946
10.1038/nbt1288
10.1590/s0102-865020170090000005
10.1111/prd.12087
ContentType Journal Article
Copyright This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright_xml – notice: This work is licensed under a Creative Commons Attribution 4.0 International License.
DBID AAYXX
CITATION
GPN
DOA
DOI 10.1590/s2175-97902021000x2e20417
DatabaseName CrossRef
SciELO
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
DatabaseTitleList

Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 2175-9790
ExternalDocumentID oai_doaj_org_article_f9a9c089ecda45b2867b1a6776320687
S1984_82502022000100772
10_1590_s2175_97902021000x2e20417
GroupedDBID ---
5VS
7X7
8FI
8FJ
AAYXX
ABUWG
ABXHO
ADBBV
AENEX
AFKRA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
APOWU
AZFZN
BAWUL
BCNDV
BENPR
CCPQU
CITATION
DIK
DU5
FYUFA
GROUPED_DOAJ
GX1
HMCUK
IPNFZ
KQ8
M~E
OK1
PIMPY
RIG
RSC
SCD
UKHRP
GPN
ID FETCH-LOGICAL-c361t-110105c8cc9475f52ae8d3676ef679f7ed451c96a2ea32018a7ffb5243955f9f3
IEDL.DBID DOA
ISSN 2175-9790
IngestDate Thu Jul 04 21:08:24 EDT 2024
Wed Sep 25 03:34:33 EDT 2024
Fri Aug 23 01:26:37 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Medicinal plants
Toxicity test
Products with antimicrobial action
Anacardiaceae
Language English
Portuguese
License This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c361t-110105c8cc9475f52ae8d3676ef679f7ed451c96a2ea32018a7ffb5243955f9f3
ORCID 0000-0001-8975-7162
0000-0002-3166-709X
0000-0002-3570-9904
OpenAccessLink https://doaj.org/article/f9a9c089ecda45b2867b1a6776320687
ParticipantIDs doaj_primary_oai_doaj_org_article_f9a9c089ecda45b2867b1a6776320687
scielo_journals_S1984_82502022000100772
crossref_primary_10_1590_s2175_97902021000x2e20417
PublicationCentury 2000
PublicationDate 2022-01-01
PublicationDateYYYYMMDD 2022-01-01
PublicationDate_xml – month: 01
  year: 2022
  text: 2022-01-01
  day: 01
PublicationDecade 2020
PublicationTitle Brazilian Journal of Pharmaceutical Sciences
PublicationTitleAlternate Braz. J. Pharm. Sci
PublicationYear 2022
Publisher Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Universidade de São Paulo
Publisher_xml – name: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
– name: Universidade de São Paulo
References Hsieh SL (ref18) 2014; 66
Ennigrou A (ref12) 2017; 108
Gilbert B (ref16) 2011; 6
Luize PS (ref20) 2005; 41
Silva DR (ref35) 2019; 33
(ref8) 2008; 28
Moura TFAL (ref25) 2011; 21
Fouche G (ref14) 2008; 119
Barbosa LCA (ref3) 2007; 30
Scott MG (ref32) 2007; 25
(ref7) 2009; 29
Macedo DG (ref22) 2020; 128
Roberts RA (ref30) 2015; 69
Shoemaker RH (ref36) 2006; 6
Łukaszuk C (ref21) 2017; 5
Araujo GS (ref2) 2018; 17
Dannenberg GS (ref9) 2019; 95
Pathak AK (ref29) 2012; 20
Wall G (ref38) 2019; 52
(ref19) 2009; 3
Silva BG (ref34) 2019; 206
Rochelle SLA (ref31) 2016; 87
Swidergall M (ref37) 2017; 13
Bitu VCN (ref5) 2015; 18
Zhang Y (ref40) 2018; 99
Freires IA (ref15) 2017; 34
Matsuo AL (ref23) 2011; 411
Carvalho M (ref6) 2013; 15
Estevão LRM (ref13) 2017; 32
Oliveira MS (ref28) 2018; 12
Do Nascimento AF (ref11) 2012; 7
Bendaoud H (ref4) 2010; 75
Holetz FB (ref17) 2002; 97
Monks A (ref24) 1991; 83
Silva BG (ref33) 2017; 130
Adams RP (ref1) 2007
De la Fuente-Núñez C (ref10) 2013; 16
Newman DJ (ref27) 2016; 79
Muller PY (ref26) 2012; 11
Wang H (ref39) 2016; 11
Scott, MG; Dullaghan, E; Mookherjee, N; Glavas, N; Waldbrook, M; Thompson, A 2007; 25
Gilbert, B; Favoreto, R 2011; 6
Moura, TFAL; Raffin, FN; Santos, ALR 2011; 21
Pathak, AK; Sharma, S; Shrivastva, P 2012; 20
Wall, G; Montelongo-Jauregui, D; Vidal Bonifacio, B; Lopez-Ribot, JL; Uppuluri, P 2019; 52
Silva, BG; Foglio, MA; Rosa, PTV; Taranto, OP; Fileti, AMF 2019; 206
Silva, DR; Rosalen, PL; Freires, IA; Sardi, JCO; Lima, RF; Lazarini, JG 2019; 33
De la Fuente-Núñez, C; Reffuveille, F; Fernández, L 2013; 16
Luize, PS; Tiuman, TS; Morello, LG; Maza, PK; Ueda-Nakamura, T; Filho, BPD 2005; 41
Bitu, VCN; Costa, JGM; Rodrigues, FFG; Colares, AV; Coutinho, HDM; Botelho, MA 2015; 18
Macedo, DG; Souza, MMA; Morais-Braga, MFB; Coutinho, HDM; Santos, ATL; Machado, AJT 2020; 128
Freires, IA; Sardi, JCO; de Castro, RD; Rosalen, PL 2017; 34
Matsuo, AL; Figueiredo, CR; Arruda, DC; Pereira, FV; Scutti, JAB; Massaoka, MH 2011; 411
Rochelle, SLA; Sardi, JCO; Freires, IA; Galvão, LCC; Lazarini, JG; Alencar, SM 2016; 87
Do Nascimento, AF; da Camara, CAG; de Moraes, MM; Ramos, CS 2012; 7
2009; 29
Carvalho, M; Melo, A; Aragão, C; Raffin, FN; Moura, TFAL 2013; 15
Newman, DJ; Cragg, GM 2016; 79
Ennigrou, A; Casabianca, H; Laarif, A; Hanchi, B; Hosni, K 2017; 108
Silva, BG; Fileti, AMF; Foglio, MA; Ruiz, ALTG; Rosa, PTV 2017; 130
Shoemaker, RH 2006; 6
Araujo, GS; Santos, EB; Silva, PPS; Oliveira, VJS; Brito, NM 2018; 17
Hsieh, SL; Li, YC; Chang, WC; Chung, JG; Hsieh, LC; Wu, CC 2014; 66
Monks, A; Scudiero, D; Skehan, P; Shoemaker, R; Paull, K; Vistica, D 1991; 83
Łukaszuk, C; Krajewska-kułak, E; Kułak, W 2017; 5
Estevão, LRM; Simões, RS; Cassini-Vieira, P; Canesso, MCC; Barcelos, LS; Rachid, MA 2017; 32
Oliveira, MS; Gontijo, SL; Teixeira, MS; Texeira, KIR; Takashi, JA; Millan, RDS 2018; 12
Wang, H; Xu, YC; Hsueh, PR 2016; 11
2008; 28
Swidergall, M; Filler, SG 2017; 13
Barbosa, LCA; Demuner, AJ; Clemente, AD 2007; 30
Dannenberg, GS; Funck, GD; Silva, WP; Fiorentini, AM 2019; 95
Muller, PY; Milton, MN 2012; 11
Fouche, G; Cragg, GM; Pillay, P; Kolesnikova, N; Maharaj, VJ; Senabe, J 2008; 119
2009; 3
Zhang, Y 2018; 99
Holetz, FB; Pessini, GL; Sanches, NR; Cortez, DA; Nakamura, CV; Filho, BP 2002; 97
Roberts, RA; Darveau, RP 2015; 69
Adams, RP 2007
Bendaoud, H; Romdhane, M; Souchard, JP; Cazaux, S; Bouajila, J 2010; 75
References_xml – volume: 18
  start-page: 647
  issue: 3
  year: 2015
  ident: ref5
  article-title: Effect of Collection Time on Composition of Essential Oil of Schauer (Verbenaceae) Growing in Northeast Brazil
  publication-title: J Essent Oil-Bear Plants
  doi: 10.1080/0972060X.2014.935043
  contributor:
    fullname: Bitu VCN
– volume: 97
  start-page: 1027
  issue: 7
  year: 2002
  ident: ref17
  article-title: Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases
  publication-title: Mem Inst Oswaldo Cruz
  doi: 10.1590/S0074-02762002000700017
  contributor:
    fullname: Holetz FB
– volume: 21
  start-page: 532
  issue: 3
  year: 2011
  ident: ref25
  article-title: Evaluation of a preservative system in a gel containing hydroalcoholic extract of Schinus terebinthifolius
  publication-title: Rev Bras Farmacogn
  doi: 10.1590/S0102-695X2011005000102
  contributor:
    fullname: Moura TFAL
– volume: 29
  year: 2009
  ident: ref7
– volume: 11
  start-page: 751
  issue: 10
  year: 2012
  ident: ref26
  article-title: The determination and interpretation of the therapeutic index in drug development
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd3801
  contributor:
    fullname: Muller PY
– volume: 20
  start-page: 70
  issue: 1
  year: 2012
  ident: ref29
  article-title: Multi-species biofilm of Candida albicans and non-Candida albicans Candida species on acrylic substrate
  publication-title: J Appl Oral Sci
  doi: 10.1590/S1678-77572012000100013
  contributor:
    fullname: Pathak AK
– volume: 108
  start-page: 407
  year: 2017
  ident: ref12
  article-title: Maturation-related changes in phytochemicals and biological activities of the Brazilian pepper tree (Schinus terebinthifolius Raddi) fruits
  publication-title: S Afr J Bot
  doi: 10.1016/j.sajb.2016.09.005
  contributor:
    fullname: Ennigrou A
– volume: 411
  start-page: 449
  issue: 29
  year: 2011
  ident: ref23
  article-title: Pinene isolated from Schinus terebinthifolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model
  publication-title: Biochem Bioph Res Co
  doi: 10.1016/j.bbrc.2011.06.176
  contributor:
    fullname: Matsuo AL
– year: 2007
  ident: ref1
  contributor:
    fullname: Adams RP
– volume: 34
  start-page: 681
  issue: 4
  year: 2017
  ident: ref15
  article-title: Alternative Animal and Non-Animal Models for Drug Discovery and Development: Bonus or Burden?
  publication-title: Pharm Res
  doi: 10.1007/s11095-016-2069-z
  contributor:
    fullname: Freires IA
– volume: 41
  start-page: 85
  issue: 1
  year: 2005
  ident: ref20
  article-title: Effects of medicinal plant extracts on growth of Leishmania (L.) amazonensis and Trypanosoma cruzi
  publication-title: Braz J Pharm Sci
  contributor:
    fullname: Luize PS
– volume: 87
  start-page: 150
  year: 2016
  ident: ref31
  article-title: The anti-biofilm potential of commonly discarded agro-industrial residues against opportunistic pathogens
  publication-title: Ind Crop Prod
  doi: 10.1016/j.indcrop.2016.03.044
  contributor:
    fullname: Rochelle SLA
– volume: 30
  start-page: 1959
  issue: 8
  year: 2007
  ident: ref3
  article-title: Seasonal variation in the composition of volatile oils from Schinus Terebinthifolius Raddi
  publication-title: Quim Nova
  doi: 10.1590/S0100-40422007000800030
  contributor:
    fullname: Barbosa LCA
– volume: 79
  start-page: 629
  issue: 3
  year: 2016
  ident: ref27
  article-title: Natural Products as Sources of New Drugs from 1981 to 2014
  publication-title: J Nat Prod
  doi: 10.1021/acs.jnatprod.5b01055
  contributor:
    fullname: Newman DJ
– volume: 11
  start-page: 1461
  issue: 11
  year: 2016
  ident: ref39
  article-title: Epidemiology of candidemia and antifungal susceptibility in invasive Candida species in the Asia-Pacific region
  publication-title: Future Microbiol
  doi: 10.2217/fmb-2016-0099
  contributor:
    fullname: Wang H
– volume: 119
  start-page: 455
  issue: 3
  year: 2008
  ident: ref14
  article-title: In vitro anticancer screening of South African plants
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2008.07.005
  contributor:
    fullname: Fouche G
– volume: 128
  start-page: 9
  year: 2020
  ident: ref22
  article-title: Seasonality influence on the chemical composition and antifungal activity of Psidium myrtoides O. Berg
  publication-title: S Afr J Bot
  doi: 10.1016/j.sajb.2019.10.009
  contributor:
    fullname: Macedo DG
– volume: 13
  issue: 1
  year: 2017
  ident: ref37
  article-title: Oropharyngeal Candidiasis: Fungal Invasion and Epithelial Cell Responses
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1006056
  contributor:
    fullname: Swidergall M
– volume: 95
  start-page: 115
  year: 2019
  ident: ref9
  article-title: Essential oil from pink pepper (Schinus terebinthifolius Raddi): Chemical composition, antibacterial activity and mechanism of action
  publication-title: Food Control
  doi: 10.1016/j.foodcont.2018.07.034
  contributor:
    fullname: Dannenberg GS
– volume: 7
  start-page: 129
  issue: 1
  year: 2012
  ident: ref11
  article-title: Essential oil composition and acaricidal activity of Schinus terebinthifolius from Atlantic forest of Pernambuco, Brazil against Tetranychus urticae
  publication-title: Nat Prod Commun
  contributor:
    fullname: Do Nascimento AF
– volume: 130
  start-page: 10
  year: 2017
  ident: ref33
  article-title: Supercritical carbono dioxide extraction of compounds from Schinus terebinthifolius Raddi fruits: Effects of operating conditions on global yield, volatile compounds, and antiproliferative activity against human tumor cell lines
  publication-title: J Supercrit Fluid
  doi: 10.1016/j.supflu.2017.07.006
  contributor:
    fullname: Silva BG
– volume: 6
  start-page: 813
  issue: 10
  year: 2006
  ident: ref36
  article-title: The NCI60 human tumour cell line anticancer drug screen
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc1951
  contributor:
    fullname: Shoemaker RH
– volume: 33
  year: 2019
  ident: ref35
  article-title: Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action
  publication-title: Braz Oral Res
  doi: 10.1590/1807-3107bor-2019.vol33.0023
  contributor:
    fullname: Silva DR
– volume: 52
  start-page: 1
  year: 2019
  ident: ref38
  article-title: Candida albicans biofilm growth and dispersal: contributions to pathogenesis
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2019.04.001
  contributor:
    fullname: Wall G
– volume: 17
  start-page: 43
  issue: 1
  year: 2018
  ident: ref2
  article-title: Ethnobotanical survey of plant species used in dentistry in the reconcavo baiano, Brazil
  publication-title: Senare
  contributor:
    fullname: Araujo GS
– volume: 75
  start-page: 466
  issue: 6
  year: 2010
  ident: ref4
  article-title: Chemical composition and anticancer and antioxidant activities of Schinus Molle L. and Schinus terebinthifolius Raddi berries essential oils
  publication-title: J Food Sci
  doi: 10.1111/j.1750-3841.2010.01711.x
  contributor:
    fullname: Bendaoud H
– volume: 99
  start-page: 883
  year: 2018
  ident: ref40
  article-title: Human oral microbiota and its modulation for oral health
  publication-title: Biomed Pharmacother
  doi: 10.1016/j.biopha.2018.01.146
  contributor:
    fullname: Zhang Y
– volume: 16
  start-page: 580
  issue: 5
  year: 2013
  ident: ref10
  article-title: Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2013.06.013
  contributor:
    fullname: De la Fuente-Núñez C
– volume: 28
  start-page: 13
  year: 2008
  ident: ref8
– volume: 6
  start-page: 43
  issue: 1
  year: 2011
  ident: ref16
  article-title: Schinus terebinthifolius Raddi
  publication-title: Rev Fitos
  doi: 10.32712/2446-4775.2011.158
  contributor:
    fullname: Gilbert B
– volume: 15
  start-page: 158
  issue: 1
  year: 2013
  ident: ref6
  article-title: Schinus terebinthifolius Raddi: chemical composition, biological properties and toxicity
  publication-title: Rev Bras Plantas Med
  doi: 10.1590/S1516-05722013000100022
  contributor:
    fullname: Carvalho M
– volume: 5
  year: 2017
  ident: ref21
  article-title: Retrospective observation of drug susceptibility of Candida strains in the years 1999, 2004, and 2015
  publication-title: PeerJ
  doi: 10.7717/peerj.3038
  contributor:
    fullname: Łukaszuk C
– volume: 83
  start-page: 757
  issue: 11
  year: 1991
  ident: ref24
  article-title: Feasibility of a high-flux anticancer drug screen using a diversepanel of cultured human tumor cell lines
  publication-title: J Natl Cancer Instit
  doi: 10.1093/jnci/83.11.757
  contributor:
    fullname: Monks A
– volume: 12
  start-page: 135
  issue: 2
  year: 2018
  ident: ref28
  article-title: Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
  publication-title: Rev Fitos
  doi: 10.5935/2446-4775.20180013
  contributor:
    fullname: Oliveira MS
– volume: 206
  start-page: 619
  issue: 5
  year: 2019
  ident: ref34
  article-title: Optimization of hydrodistillation and In vitro anticancer activity of essential oil from Schinus terebinthifolius Raddi fruits
  publication-title: Chem Eng Com
  doi: 10.1080/00986445.2018.1515074
  contributor:
    fullname: Silva BG
– volume: 66
  start-page: 970
  issue: 6
  year: 2014
  ident: ref18
  article-title: Induction of necrosis in human liver tumor cells by α-phellandrene
  publication-title: Nutr Cancer
  doi: 10.1080/01635581.2014.936946
  contributor:
    fullname: Hsieh SL
– volume: 25
  start-page: 465
  issue: 4
  year: 2007
  ident: ref32
  article-title: An antiinfective peptide that selectively modulates the innate immune response
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt1288
  contributor:
    fullname: Scott MG
– volume: 3
  start-page: 1
  year: 2009
  ident: ref19
– volume: 32
  start-page: 726
  issue: 9
  year: 2017
  ident: ref13
  article-title: Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
  publication-title: Acta Bras Cir
  doi: 10.1590/s0102-865020170090000005
  contributor:
    fullname: Estevão LRM
– volume: 69
  start-page: 18
  issue: 1
  year: 2015
  ident: ref30
  article-title: Microbial Protection and Virulence in Periodontal Tissue as a Function of Polymicrobial Communities: Symbiosis and Dysbiosis
  publication-title: Periodontol 2000
  doi: 10.1111/prd.12087
  contributor:
    fullname: Roberts RA
– volume: 21
  start-page: 532
  issue: 3
  year: 2011
  end-page: 536
  article-title: Evaluation of a preservative system in a gel containing hydroalcoholic extract of Schinus terebinthifolius
  publication-title: Rev Bras Farmacogn
  contributor:
    fullname: Moura, TFAL; Raffin, FN; Santos, ALR
– volume: 6
  start-page: 813
  issue: 10
  year: 2006
  end-page: 823
  article-title: The NCI60 human tumour cell line anticancer drug screen
  publication-title: Nat Rev Cancer
  contributor:
    fullname: Shoemaker, RH
– volume: 79
  start-page: 629
  issue: 3
  year: 2016
  end-page: 661
  article-title: Natural Products as Sources of New Drugs from 1981 to 2014
  publication-title: J Nat Prod
  contributor:
    fullname: Newman, DJ; Cragg, GM
– volume: 7
  start-page: 129
  issue: 1
  year: 2012
  end-page: 132
  article-title: Essential oil composition and acaricidal activity of Schinus terebinthifolius from Atlantic forest of Pernambuco, Brazil against Tetranychus urticae
  publication-title: Nat Prod Commun
  contributor:
    fullname: Do Nascimento, AF; da Camara, CAG; de Moraes, MM; Ramos, CS
– volume: 87
  start-page: 150
  year: 2016
  end-page: 160
  article-title: The anti-biofilm potential of commonly discarded agro-industrial residues against opportunistic pathogens
  publication-title: Ind Crop Prod
  contributor:
    fullname: Rochelle, SLA; Sardi, JCO; Freires, IA; Galvão, LCC; Lazarini, JG; Alencar, SM
– volume: 206
  start-page: 619
  issue: 5
  year: 2019
  end-page: 629
  article-title: Optimization of hydrodistillation and In vitro anticancer activity of essential oil from Schinus terebinthifolius Raddi fruits
  publication-title: Chem Eng Com
  contributor:
    fullname: Silva, BG; Foglio, MA; Rosa, PTV; Taranto, OP; Fileti, AMF
– volume: 130
  start-page: 10
  year: 2017
  end-page: 16
  article-title: Supercritical carbono dioxide extraction of compounds from Schinus terebinthifolius Raddi fruits: Effects of operating conditions on global yield, volatile compounds, and antiproliferative activity against human tumor cell lines
  publication-title: J Supercrit Fluid
  contributor:
    fullname: Silva, BG; Fileti, AMF; Foglio, MA; Ruiz, ALTG; Rosa, PTV
– volume: 28
  start-page: 13
  year: 2008
  end-page: 13
  publication-title: Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts - M27-A3
– volume: 99
  start-page: 883
  year: 2018
  end-page: 893
  article-title: Human oral microbiota and its modulation for oral health
  publication-title: Biomed Pharmacother
  contributor:
    fullname: Zhang, Y
– year: 2007
  publication-title: Identification of essential oil components by Gas Chromatography/Mass Spectrometry
  contributor:
    fullname: Adams, RP
– volume: 17
  start-page: 43
  issue: 1
  year: 2018
  end-page: 50
  article-title: Ethnobotanical survey of plant species used in dentistry in the reconcavo baiano, Brazil
  publication-title: Senare
  contributor:
    fullname: Araujo, GS; Santos, EB; Silva, PPS; Oliveira, VJS; Brito, NM
– volume: 108
  start-page: 407
  year: 2017
  end-page: 415
  article-title: Maturation-related changes in phytochemicals and biological activities of the Brazilian pepper tree (Schinus terebinthifolius Raddi) fruits
  publication-title: S Afr J Bot
  contributor:
    fullname: Ennigrou, A; Casabianca, H; Laarif, A; Hanchi, B; Hosni, K
– volume: 3
  start-page: 1
  year: 2009
  end-page: 42
  publication-title: (ISO - 10993-5). Biological evaluation of medical devices -Part 5: Tests for in vitro cytotoxicity
– volume: 13
  issue: 1
  year: 2017
  article-title: Oropharyngeal Candidiasis: Fungal Invasion and Epithelial Cell Responses
  publication-title: PLoS Pathog
  contributor:
    fullname: Swidergall, M; Filler, SG
– volume: 32
  start-page: 726
  issue: 9
  year: 2017
  end-page: 735
  article-title: Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
  publication-title: Acta Bras Cir
  contributor:
    fullname: Estevão, LRM; Simões, RS; Cassini-Vieira, P; Canesso, MCC; Barcelos, LS; Rachid, MA
– volume: 69
  start-page: 18
  issue: 1
  year: 2015
  end-page: 27
  article-title: Microbial Protection and Virulence in Periodontal Tissue as a Function of Polymicrobial Communities: Symbiosis and Dysbiosis
  publication-title: Periodontol 2000
  contributor:
    fullname: Roberts, RA; Darveau, RP
– volume: 128
  start-page: 9
  year: 2020
  end-page: 17
  article-title: Seasonality influence on the chemical composition and antifungal activity of Psidium myrtoides O. Berg
  publication-title: S Afr J Bot
  contributor:
    fullname: Macedo, DG; Souza, MMA; Morais-Braga, MFB; Coutinho, HDM; Santos, ATL; Machado, AJT
– volume: 11
  start-page: 1461
  issue: 11
  year: 2016
  end-page: 1477
  article-title: Epidemiology of candidemia and antifungal susceptibility in invasive Candida species in the Asia-Pacific region
  publication-title: Future Microbiol
  contributor:
    fullname: Wang, H; Xu, YC; Hsueh, PR
– volume: 18
  start-page: 647
  issue: 3
  year: 2015
  end-page: 653
  article-title: Effect of Collection Time on Composition of Essential Oil of Schauer (Verbenaceae) Growing in Northeast Brazil
  publication-title: J Essent Oil-Bear Plants
  contributor:
    fullname: Bitu, VCN; Costa, JGM; Rodrigues, FFG; Colares, AV; Coutinho, HDM; Botelho, MA
– volume: 15
  start-page: 158
  issue: 1
  year: 2013
  end-page: 169
  article-title: Schinus terebinthifolius Raddi: chemical composition, biological properties and toxicity
  publication-title: Rev Bras Plantas Med
  contributor:
    fullname: Carvalho, M; Melo, A; Aragão, C; Raffin, FN; Moura, TFAL
– volume: 29
  year: 2009
  publication-title: Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically. M07-A8
– volume: 34
  start-page: 681
  issue: 4
  year: 2017
  end-page: 686
  article-title: Alternative Animal and Non-Animal Models for Drug Discovery and Development: Bonus or Burden?
  publication-title: Pharm Res
  contributor:
    fullname: Freires, IA; Sardi, JCO; de Castro, RD; Rosalen, PL
– volume: 95
  start-page: 115
  year: 2019
  end-page: 120
  article-title: Essential oil from pink pepper (Schinus terebinthifolius Raddi): Chemical composition, antibacterial activity and mechanism of action
  publication-title: Food Control
  contributor:
    fullname: Dannenberg, GS; Funck, GD; Silva, WP; Fiorentini, AM
– volume: 20
  start-page: 70
  issue: 1
  year: 2012
  end-page: 75
  article-title: Multi-species biofilm of Candida albicans and non-Candida albicans Candida species on acrylic substrate
  publication-title: J Appl Oral Sci
  contributor:
    fullname: Pathak, AK; Sharma, S; Shrivastva, P
– volume: 6
  start-page: 43
  issue: 1
  year: 2011
  end-page: 56
  article-title: Schinus terebinthifolius Raddi
  publication-title: Rev Fitos
  contributor:
    fullname: Gilbert, B; Favoreto, R
– volume: 97
  start-page: 1027
  issue: 7
  year: 2002
  end-page: 1031
  article-title: Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases
  publication-title: Mem Inst Oswaldo Cruz
  contributor:
    fullname: Holetz, FB; Pessini, GL; Sanches, NR; Cortez, DA; Nakamura, CV; Filho, BP
– volume: 12
  start-page: 135
  issue: 2
  year: 2018
  end-page: 146
  article-title: Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
  publication-title: Rev Fitos
  contributor:
    fullname: Oliveira, MS; Gontijo, SL; Teixeira, MS; Texeira, KIR; Takashi, JA; Millan, RDS
– volume: 5
  year: 2017
  article-title: Retrospective observation of drug susceptibility of Candida strains in the years 1999, 2004, and 2015
  publication-title: PeerJ
  contributor:
    fullname: Łukaszuk, C; Krajewska-kułak, E; Kułak, W
– volume: 411
  start-page: 449
  issue: 29
  year: 2011
  end-page: 454
  article-title: Pinene isolated from Schinus terebinthifolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model
  publication-title: Biochem Bioph Res Co
  contributor:
    fullname: Matsuo, AL; Figueiredo, CR; Arruda, DC; Pereira, FV; Scutti, JAB; Massaoka, MH
– volume: 33
  year: 2019
  article-title: Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action
  publication-title: Braz Oral Res
  contributor:
    fullname: Silva, DR; Rosalen, PL; Freires, IA; Sardi, JCO; Lima, RF; Lazarini, JG
– volume: 119
  start-page: 455
  issue: 3
  year: 2008
  end-page: 461
  article-title: In vitro anticancer screening of South African plants
  publication-title: J Ethnopharmacol
  contributor:
    fullname: Fouche, G; Cragg, GM; Pillay, P; Kolesnikova, N; Maharaj, VJ; Senabe, J
– volume: 66
  start-page: 970
  issue: 6
  year: 2014
  end-page: 979
  article-title: Induction of necrosis in human liver tumor cells by α-phellandrene
  publication-title: Nutr Cancer
  contributor:
    fullname: Hsieh, SL; Li, YC; Chang, WC; Chung, JG; Hsieh, LC; Wu, CC
– volume: 52
  start-page: 1
  year: 2019
  end-page: 6
  article-title: Candida albicans biofilm growth and dispersal: contributions to pathogenesis
  publication-title: Curr Opin Microbiol
  contributor:
    fullname: Wall, G; Montelongo-Jauregui, D; Vidal Bonifacio, B; Lopez-Ribot, JL; Uppuluri, P
– volume: 16
  start-page: 580
  issue: 5
  year: 2013
  end-page: 589
  article-title: Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies
  publication-title: Curr Opin Microbiol
  contributor:
    fullname: De la Fuente-Núñez, C; Reffuveille, F; Fernández, L
– volume: 41
  start-page: 85
  issue: 1
  year: 2005
  end-page: 94
  article-title: Effects of medicinal plant extracts on growth of Leishmania (L.) amazonensis and Trypanosoma cruzi
  publication-title: Braz J Pharm Sci
  contributor:
    fullname: Luize, PS; Tiuman, TS; Morello, LG; Maza, PK; Ueda-Nakamura, T; Filho, BPD
– volume: 75
  start-page: 466
  issue: 6
  year: 2010
  end-page: 472
  article-title: Chemical composition and anticancer and antioxidant activities of Schinus Molle L. and Schinus terebinthifolius Raddi berries essential oils
  publication-title: J Food Sci
  contributor:
    fullname: Bendaoud, H; Romdhane, M; Souchard, JP; Cazaux, S; Bouajila, J
– volume: 30
  start-page: 1959
  issue: 8
  year: 2007
  end-page: 1965
  article-title: Seasonal variation in the composition of volatile oils from Schinus Terebinthifolius Raddi
  publication-title: Quim Nova
  contributor:
    fullname: Barbosa, LCA; Demuner, AJ; Clemente, AD
– volume: 11
  start-page: 751
  issue: 10
  year: 2012
  end-page: 761
  article-title: The determination and interpretation of the therapeutic index in drug development
  publication-title: Nat Rev Drug Discov
  contributor:
    fullname: Muller, PY; Milton, MN
– volume: 83
  start-page: 757
  issue: 11
  year: 1991
  end-page: 766
  article-title: Feasibility of a high-flux anticancer drug screen using a diversepanel of cultured human tumor cell lines
  publication-title: J Natl Cancer Instit
  contributor:
    fullname: Monks, A; Scudiero, D; Skehan, P; Shoemaker, R; Paull, K; Vistica, D
– volume: 25
  start-page: 465
  issue: 4
  year: 2007
  end-page: 472
  article-title: An antiinfective peptide that selectively modulates the innate immune response
  publication-title: Nat Biotechnol
  contributor:
    fullname: Scott, MG; Dullaghan, E; Mookherjee, N; Glavas, N; Waldbrook, M; Thompson, A
SSID ssj0001548945
Score 2.2758222
Snippet Abstract Schinus terebinthifolia Raddi green fruits essential oil (EO) was evaluated regarding its phytochemical profile, antimicrobial and cytotoxic...
SourceID doaj
scielo
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
SubjectTerms Anacardiaceae
Medicinal plants
PHARMACOLOGY & PHARMACY
Products with antimicrobial action
Toxicity test
Title Biological properties of Schinus terebinthifolia Raddi essential oil
URI http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100772&lng=en&tlng=en
https://doaj.org/article/f9a9c089ecda45b2867b1a6776320687
Volume 58
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LSwMxEA7iQbyIT6wvIoheXGyyySY5-hZBER_QW0iyCRZKW2wF_ffObKrtQfDiZQ8LmyzfZJiZMPN9hBzUoRRJeVP4kHQhEi8L7wwvPBe19Mwl2aiW3N1XNy_itiM7M1Jf2BOW6YEzcCfJOBPa2sRQOyE915WCJSoFfsHblc5z5EzOFFN5PlhoI-QC2W8kfkz7ZAS5tyyMMpAfcbzU_uCRt0UjVDYNSA1vP7KGgmP1ZiPN1TJZmqSI9DT_2gqZi_1VcviQOaY_j-nzdGRqdEwP6cOUffpzjVxkdUnEng7xpv0NKVPpINEnbJt8H1FAMkI9PH7tpkGv6-gj9hRR5BDvg7v36KDbWycvV5fP5zfFRCqhCGXFxgUEcUiUgg7BCCWT5C7qGsnYYqqUSSrWQrJgKsejA9yYdiolLzmkI1Imk8oNMt8f9OMmod7V3hueoi61iLXxSMCuKsc80yGWvEX4N152mBkxLFYSALJtQLa_gNwiZ4jszwdIat28AFPbiantX6ZukaNsFzvxs5F9YkYLC1UubohTR9j0ofjWf2y3TRZx0XzfskPmx2_vcRcykLHfaw4bPK877AtZENUJ
link.rule.ids 230,315,786,790,870,891,2115,27957,27958
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Biological+properties+of+Schinus+terebinthifolia+Raddi+essential+oil&rft.jtitle=Brazilian+Journal+of+Pharmaceutical+Sciences&rft.au=Priscilla+Guimar%C3%A3es+Silva+Vasconcelos&rft.au=%C3%89rika+Ponchet+Alves&rft.au=Carolina+Medeiros+de+Almeida+Maia&rft.au=Arella+Cristina+Muniz+Brito&rft.date=2022-01-01&rft.pub=Universidade+de+S%C3%A3o+Paulo&rft.eissn=2175-9790&rft.volume=58&rft_id=info:doi/10.1590%2Fs2175-97902021000x2e20417&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_f9a9c089ecda45b2867b1a6776320687
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2175-9790&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2175-9790&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2175-9790&client=summon