Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells

• Published in: Journal of cellular biochemistry Vol. 103; no. 5; pp. 1536 - 1550
• Main Authors: Wo, Yan-bo, Zhu, Dan-yan, Hu, Ying, Wang, Zhi-Qiang, Liu, Jian, Lou, Yi-Jia
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2008
• Subjects: Animals; cardiac differentiation; Cell Differentiation - drug effects; Cell Line; embryonic stem cell; Embryonic Stem Cells - cytology; Embryonic Stem Cells - metabolism; Enzyme Inhibitors - pharmacology; Flavonoids - pharmacology; icariin; icaritin; MAP Kinase Signaling System - drug effects; Mice; Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 3 - metabolism; Myocytes, Cardiac - cytology; Myocytes, Cardiac - metabolism; NADPH Oxidase 4; NADPH Oxidases - antagonists & inhibitors; NADPH Oxidases - metabolism; p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases - metabolism; prenylflavonoid; Reactive Oxygen Species

The significant promoting effects of some prenylflavonoids on cardiac differentiation of mouse embryonic stem (ES) cells via reactive oxygen species (ROS) signaling pathway were investigated. The most effective differentiation was facilitated by icariin (ICA), followed by icaritin (ICT), while desme...