Activation of the extracellular signal-regulated kinases 1 and 2 by glial cell line-derived neurotrophic factor and its relation to neuroprotection in a mouse model of Parkinson's disease

• Published in: Journal of neuroscience research Vol. 86; no. 9; pp. 2039 - 2049
• Main Authors: Lindgren, Niklas, Leak, Rehana K., Carlson, Kirsten M., Smith, Amanda D., Zigmond, Michael J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2008
• Subjects: 6-hydroxydopamine; Akt; Animals; Disease Models, Animal; dopamine; Enzyme Activation; Glial Cell Line-Derived Neurotrophic Factor - pharmacology; GRFα1; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1 - drug effects; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - drug effects; Mitogen-Activated Protein Kinase 3 - metabolism; Neuroglia - enzymology; neuroprotection; neurotrophic factors; Oxidopamine - antagonists & inhibitors; Oxidopamine - toxicity; Parkinsonian Disorders - enzymology; Parkinsonian Disorders - physiopathology; RET; striatum

Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDNF into t...