Evaluation of Blood Cytotoxicity Against Tumor Cells Using a Live‐Cell Imaging Platform

• Published in: Cytometry. Part A Vol. 107; no. 5; pp. 344 - 352
• Main Authors: Salvia, Roser, Rico, Laura G., Morán, Teresa, Olszowy, Michael W., Ward, Michael D., Petriz, Jordi
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2025; Wiley Subscription Services, Inc
• Subjects: Biomarkers; Blood; blood cytotoxicity; cancer; Cell Line, Tumor; Cytotoxicity; Cytotoxicity, Immunologic - immunology; Humans; Imaging techniques; Immune system; Killer Cells, Natural - immunology; live‐cell imaging; Lung cancer; Lung Neoplasms - blood; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Lymphocytes; Lymphocytes T; Medical imaging; Natural killer cells; Reagents; T-Lymphocytes, Cytotoxic - immunology; Toxicity testing; Tumor cells; Tumors; blood cytotoxicity; cancer; live‐cell imaging

ABSTRACT Cellular cytotoxicity is an important mechanism of the immune system to clear infections and eliminate tumor cells. Its two main mediators are cytotoxic T lymphocytes and natural killer (NK) cells. In lung cancer, intratumoral NK cells show reduced cytolytic potential and one third of patie...