Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC

• Published in: The Journal of immunology (1950) Vol. 155; no. 1; pp. 473 - 488
• Main Authors: Rowell, JF, Stanhope, PE, Siliciano, RF
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.07.1995
• Subjects: AIDS/HIV; Antigen Presentation - immunology; B-Lymphocytes - chemistry; CD4-Positive T-Lymphocytes - immunology; Cell Line; Clone Cells; Endocytosis - physiology; Flow Cytometry; Genetic Vectors; HIV Envelope Protein gp120 - biosynthesis; HIV Envelope Protein gp120 - metabolism; HIV Envelope Protein gp41 - biosynthesis; HIV Envelope Protein gp41 - metabolism; HIV-1 - metabolism; HLA-D Antigens - metabolism; human immunodeficiency virus 1; Humans; Lymphocyte Activation; Viral Envelope Proteins - biosynthesis; Viral Envelope Proteins - metabolism

CD4+ T cell clones specific for the HIV-1 envelope (env) protein are able to recognize not only uninfected APC that have taken up and processed exogenous env protein, but also virally infected cells expressing the env protein. We have evaluated the hypothesis that endocytosis of endogenously synthes...