Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter

• Published in: Neuroscience letters Vol. 434; no. 3; pp. 304 - 309
• Main Authors: Boccardi, Marina, Scassellati, Catia, Ghidoni, Roberta, Testa, Cristina, Benussi, Luisa, Bonetti, Matteo, Bocchio-Chiavetto, Luisella, Gennarelli, Massimo, Binetti, Giuliano, Frisoni, Giovanni B.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 04.04.2008
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Atrophy - genetics; Atrophy - metabolism; Atrophy - physiopathology; Brain - metabolism; Brain - pathology; Brain - physiopathology; Cognition Disorders - genetics; Cognition Disorders - metabolism; Cognition Disorders - physiopathology; Cytoprotection - genetics; Dementia - genetics; Dementia - metabolism; Dementia - physiopathology; Deoxyribonucleases, Type II Site-Specific; Disease Progression; DNA Mutational Analysis; Estrogen receptor alpha; Estrogen Receptor alpha - genetics; Estrogens - metabolism; Female; Gene Frequency; Genetic Predisposition to Disease - genetics; Genetic Testing; Genotype; Heterozygote; Humans; Magnetic Resonance Imaging; Middle Aged; Morphometry; Neuroimaging; Polymorphism, Genetic - genetics; Polymorphism, Restriction Fragment Length; Postmenopause - metabolism; VBM; XbaI; Neuroimaging; VBM; Estrogen receptor alpha; XbaI; Morphometry; MR

The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies’ risk such as Alzheimer's disease (AD) or cognitive decline. In the present study, we explored whether the XbaI polymorphism leads to different gray matt...