Determination of meropenem in serum by high-performance liquid chromatography with column switching
A rapid, accurate and sensitive liquid chromatographic assay with on-line solid-phase extraction for determination of meropenem in serum is described. Sample was directly injected onto the extraction column for sample clean-up and extraction. Thereafter, using an on-line column-switching system the...
Saved in:
| Published in | Journal of Chromatography A Vol. 812; no. 1; pp. 249 - 253 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
03.07.1998
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-9673 |
| DOI | 10.1016/S0021-9673(98)00249-0 |
Cover
| Abstract | A rapid, accurate and sensitive liquid chromatographic assay with on-line solid-phase extraction for determination of meropenem in serum is described. Sample was directly injected onto the extraction column for sample clean-up and extraction. Thereafter, using an on-line column-switching system the drug was quantitatively transferred and separated on a C
18 analytical column. Ultraviolet absorption at 298 nm was used for detection. The assay was linear from 1 to 100 μg/ml. Recovery was 98.5%. Based on a 20-μl sample volume (serum–water, 1:1, v/v), detection limit was 0.1 μg/ml. An application of the method to study the pharmacokinetics of meropenem is given. |
|---|---|
| AbstractList | A rapid, accurate and sensitive liquid chromatographic assay with on-line solid-phase extraction for determination of meropenem in serum is described. Sample was directly injected onto the extraction column for sample clean-up and extraction. Thereafter, using an on-line column-switching system the drug was quantitatively transferred and separated on a C
18 analytical column. Ultraviolet absorption at 298 nm was used for detection. The assay was linear from 1 to 100 μg/ml. Recovery was 98.5%. Based on a 20-μl sample volume (serum–water, 1:1, v/v), detection limit was 0.1 μg/ml. An application of the method to study the pharmacokinetics of meropenem is given. A rapid, accurate and sensitive liquid chromatographic assay with on-line solid-phase extraction for determination of meropenem in serum is described. Sample was directly injected onto the extraction column for sample clean-up and extraction. Thereafter, using an on-line column-switching system the drug was quantitatively transferred and separated on a C18 analytical column. Ultraviolet absorption at 298 nm was used for detection. The assay was linear from 1 to 100 micrograms/ml. Recovery was 98.5%. Based on a 20-microliters sample volume (serum- water, 1:1, v/v), detection limit was 0.1 microgram/ml. An application of the method to study the pharmacokinetics of meropenem is given.A rapid, accurate and sensitive liquid chromatographic assay with on-line solid-phase extraction for determination of meropenem in serum is described. Sample was directly injected onto the extraction column for sample clean-up and extraction. Thereafter, using an on-line column-switching system the drug was quantitatively transferred and separated on a C18 analytical column. Ultraviolet absorption at 298 nm was used for detection. The assay was linear from 1 to 100 micrograms/ml. Recovery was 98.5%. Based on a 20-microliters sample volume (serum- water, 1:1, v/v), detection limit was 0.1 microgram/ml. An application of the method to study the pharmacokinetics of meropenem is given. A rapid, accurate and sensitive liquid chromatographic assay with on-line solid-phase extraction for determination of meropenem in serum is described. Sample was directly injected onto the extraction column for sample clean-up and extraction. Thereafter, using an on-line column-switching system the drug was quantitatively transferred and separated on a C18 analytical column. Ultraviolet absorption at 298 nm was used for detection. The assay was linear from 1 to 100 micrograms/ml. Recovery was 98.5%. Based on a 20-microliters sample volume (serum- water, 1:1, v/v), detection limit was 0.1 microgram/ml. An application of the method to study the pharmacokinetics of meropenem is given. |
| Author | Bompadre, S De Martinis, M Leone, L Ferrante, L |
| Author_xml | – sequence: 1 givenname: S surname: Bompadre fullname: Bompadre, S organization: Institute of Biomedical Sciences, Faculty of Medicine, University of Ancona, Monte d'Ago, 60131 Ancona, Italy – sequence: 2 givenname: L surname: Ferrante fullname: Ferrante, L organization: Institute of Biomedical Sciences, Faculty of Medicine, University of Ancona, Monte d'Ago, 60131 Ancona, Italy – sequence: 3 givenname: M surname: De Martinis fullname: De Martinis, M organization: Department of Internal Medicine, University of L'Aquila, 67100 L'Aquila, Italy – sequence: 4 givenname: L surname: Leone fullname: Leone, L organization: Institute of Biomedical Sciences, Faculty of Medicine, University of Ancona, Monte d'Ago, 60131 Ancona, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9691323$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkEtv3SAQhVmkyqv5CZFYVenCCRgbG3VRVWkelSJ10WSNMB6uqQw4gFPdfx_fR7PIJqvRmTPnaPSdoAMfPCB0TsklJZRf_SGkpIXgDbsQ7ddFVKIgB-j4bX2ETlL6SwhtSFMeokPBBWUlO0b6J2SIznqVbfA4GOwghgk8OGw9ThBnh7s1HuxqKCaIJkSnvAY82ufZ9lgPMTiVwyqqaVjjfzYPWIdxdkt2EXqwfvUZfTJqTHC2n6fo6fbm8fq-ePh99-v6x0OhGSe5MLrRfWWUbjpemapRlFS0aUlHeVmxejEEFXVHDKOdYoRVou_L0uhW1IpzTdgp-rLrnWJ4niFl6WzSMI7KQ5iTbAmpGOP1cni-P5w7B72conUqruWeyuJ_2_k6hpQiGKlt3gLKUdlRUiI32OUWu9zwlaKVW-xy80b9Lv2__6Pc910OFkYvFqJM2sLCurcRdJZ9sB80vAIDY52Z |
| CitedBy_id | crossref_primary_10_1016_S0378_4347_99_00560_5 crossref_primary_10_1016_S0731_7085_03_00366_2 crossref_primary_10_1016_j_jchromb_2007_05_043 crossref_primary_10_1016_j_jpba_2018_01_006 crossref_primary_10_1016_S0021_9673_02_00078_X crossref_primary_10_1365_s10337_009_1304_8 crossref_primary_10_1016_j_jpba_2004_11_030 crossref_primary_10_1097_01_CCM_0000190243_88133_3F crossref_primary_10_1016_j_jpba_2017_12_039 crossref_primary_10_1016_j_talanta_2008_06_045 crossref_primary_10_2478_sjecr_2022_0005 crossref_primary_10_1093_chromsci_bmz087 crossref_primary_10_1081_JLC_120015890 crossref_primary_10_1016_j_jchromb_2007_12_020 crossref_primary_10_1016_j_saa_2014_01_008 crossref_primary_10_1007_BF02491612 crossref_primary_10_1016_j_clinbiochem_2014_08_002 crossref_primary_10_1007_BF02575283 crossref_primary_10_1016_j_jchromb_2011_03_038 crossref_primary_10_1016_S0731_7085_02_00022_5 |
| Cites_doi | 10.1128/AAC.34.8.1515 10.1128/AAC.36.12.2794 10.1093/jac/27.2.219 10.2165/00003495-199550010-00007 10.1093/jac/36.suppl_A.35 10.1093/jac/24.3.311 10.1016/0378-4347(93)80107-F 10.1016/S0378-4347(96)00205-8 10.1016/0378-4347(95)00100-W 10.1080/10826079708010974 10.1111/j.1365-2710.1995.tb00642.x 10.1007/BF01964413 |
| ContentType | Journal Article |
| Copyright | 1998 Elsevier Science B.V. |
| Copyright_xml | – notice: 1998 Elsevier Science B.V. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/S0021-9673(98)00249-0 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EndPage | 253 |
| ExternalDocumentID | 9691323 10_1016_S0021_9673_98_00249_0 S0021967398002490 |
| Genre | Clinical Trial Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M -~X .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29K 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JN AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AAXUO AAYJJ ABFNM ABFRF ABJNI ABMAC ABXDB ABYKQ ACDAQ ACGFO ACGFS ACNNM ACRLP ADBBV ADECG ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFZHZ AGHFR AGUBO AGYEJ AHHHB AHPSJ AI. AIEXJ AIKHN AITUG AJBFU AJOXV AJQLL AJSZI ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC D-I DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FLBIZ FNPLU FYGXN G-Q G8K GBLVA HMU HVGLF HZ~ H~9 IH2 IHE J1W KOM M36 M41 MO0 N9A O-L O9- OAUVE OHT OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCB SCC SCH SDF SDG SDP SES SEW SPC SPCBC SSK SSZ T5K UQL VH1 WH7 WUQ XFK XPP YK3 ZGI ZKB ZMT ZXP ~02 ~G- ~KM AAHBH AATTM AAXKI AAYWO AAYXX ABDPE ACVFH ADCNI AEIPS AEUPX AFJKZ AFPUW AFXIZ AGCQF AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH CGR CUY CVF ECM EIF NPM 7X8 EFKBS |
| ID | FETCH-LOGICAL-c360t-fc7cd4fac7b64f47a1041780b162435fac9195b0f31ba30349dd22fc895a66c03 |
| IEDL.DBID | .~1 |
| ISSN | 0021-9673 |
| IngestDate | Fri Sep 05 08:10:04 EDT 2025 Wed Feb 19 02:32:31 EST 2025 Thu Apr 24 23:09:56 EDT 2025 Tue Jul 01 03:10:02 EDT 2025 Fri Feb 23 02:28:41 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Meropenem Column switching Sample preparation Antibiotics |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c360t-fc7cd4fac7b64f47a1041780b162435fac9195b0f31ba30349dd22fc895a66c03 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 9691323 |
| PQID | 80043365 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_80043365 pubmed_primary_9691323 crossref_citationtrail_10_1016_S0021_9673_98_00249_0 crossref_primary_10_1016_S0021_9673_98_00249_0 elsevier_sciencedirect_doi_10_1016_S0021_9673_98_00249_0 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 1900 |
| PublicationDate | 1998-07-03 |
| PublicationDateYYYYMMDD | 1998-07-03 |
| PublicationDate_xml | – month: 07 year: 1998 text: 1998-07-03 day: 03 |
| PublicationDecade | 1990 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Journal of Chromatography A |
| PublicationTitleAlternate | J Chromatogr A |
| PublicationYear | 1998 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Al-Meshal, Ramadan, Lofti, Shibl (BIB7) 1995; 20 Burman, Nillson-Ehle, Hutchison, Haworth, Norrby (BIB6) 1991; 27 Kelly, Hutchison, Haworth (BIB9) 1995; 36 Bompadre, Ferrante, Leone, Montesi, Possati (BIB12) 1997; 20 Leroy, Fillastre, Borsa-Lebas, Etienne, Humbert (BIB3) 1992; 36 Bax, Bastain, Featherstone, Wilkinson, Hutchinson, Haworth (BIB4) 1989; 24 Elkhaili, Niedergang, Pompei, Linger, Leveque, Jehl (BIB8) 1996; 686 Wise, Logan, Cooper, Ashby, Andrews (BIB2) 1990; 34 Bompadre, Ferrante, Alò, Leone (BIB11) 1995; 669 Wiseman, Wagstoff, Brogden, Bryson (BIB1) 1995; 50 Nilsson-Ehle, Hutchison, Haworth, Norrby (BIB5) 1991; 10 Campinos-Falco, Herraez-Hernandez, Servillano-Cabeza (BIB10) 1993; 619 Al-Meshal (10.1016/S0021-9673(98)00249-0_BIB7) 1995; 20 Nilsson-Ehle (10.1016/S0021-9673(98)00249-0_BIB5) 1991; 10 Bompadre (10.1016/S0021-9673(98)00249-0_BIB12) 1997; 20 Burman (10.1016/S0021-9673(98)00249-0_BIB6) 1991; 27 Kelly (10.1016/S0021-9673(98)00249-0_BIB9) 1995; 36 Campinos-Falco (10.1016/S0021-9673(98)00249-0_BIB10) 1993; 619 Bompadre (10.1016/S0021-9673(98)00249-0_BIB11) 1995; 669 Wiseman (10.1016/S0021-9673(98)00249-0_BIB1) 1995; 50 Wise (10.1016/S0021-9673(98)00249-0_BIB2) 1990; 34 Bax (10.1016/S0021-9673(98)00249-0_BIB4) 1989; 24 Elkhaili (10.1016/S0021-9673(98)00249-0_BIB8) 1996; 686 Leroy (10.1016/S0021-9673(98)00249-0_BIB3) 1992; 36 |
| References_xml | – volume: 36 start-page: 2794 year: 1992 ident: BIB3 publication-title: Antimicrob. Agents Chemother. – volume: 619 start-page: 177 year: 1993 ident: BIB10 publication-title: J. Chromatogr. – volume: 27 start-page: 219 year: 1991 ident: BIB6 publication-title: J. Antimicrob. Chemother. – volume: 50 start-page: 73 year: 1995 ident: BIB1 publication-title: Drugs – volume: 10 start-page: 85 year: 1991 ident: BIB5 publication-title: Eur. J. Microb. Infect. Dis. – volume: 34 start-page: 1515 year: 1990 ident: BIB2 publication-title: Antimicrob. Agents Chemother. – volume: 686 start-page: 19 year: 1996 ident: BIB8 publication-title: J. Chromatogr. B – volume: 20 start-page: 159 year: 1995 ident: BIB7 publication-title: J. Clin. Pharmacol. Ther. – volume: 669 start-page: 265 year: 1995 ident: BIB11 publication-title: J. Chromatogr. B – volume: 20 start-page: 1257 year: 1997 ident: BIB12 publication-title: J. Liq. Chromatogr. – volume: 24 start-page: 311 year: 1989 ident: BIB4 publication-title: J. Antimicrob. Chemother. – volume: 36 start-page: 35 year: 1995 ident: BIB9 publication-title: J. Antimicrob. Chemother. – volume: 34 start-page: 1515 year: 1990 ident: 10.1016/S0021-9673(98)00249-0_BIB2 publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.34.8.1515 – volume: 36 start-page: 2794 year: 1992 ident: 10.1016/S0021-9673(98)00249-0_BIB3 publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.36.12.2794 – volume: 27 start-page: 219 year: 1991 ident: 10.1016/S0021-9673(98)00249-0_BIB6 publication-title: J. Antimicrob. Chemother. doi: 10.1093/jac/27.2.219 – volume: 50 start-page: 73 year: 1995 ident: 10.1016/S0021-9673(98)00249-0_BIB1 publication-title: Drugs doi: 10.2165/00003495-199550010-00007 – volume: 36 start-page: 35 year: 1995 ident: 10.1016/S0021-9673(98)00249-0_BIB9 publication-title: J. Antimicrob. Chemother. doi: 10.1093/jac/36.suppl_A.35 – volume: 24 start-page: 311 year: 1989 ident: 10.1016/S0021-9673(98)00249-0_BIB4 publication-title: J. Antimicrob. Chemother. doi: 10.1093/jac/24.3.311 – volume: 619 start-page: 177 year: 1993 ident: 10.1016/S0021-9673(98)00249-0_BIB10 publication-title: J. Chromatogr. doi: 10.1016/0378-4347(93)80107-F – volume: 686 start-page: 19 year: 1996 ident: 10.1016/S0021-9673(98)00249-0_BIB8 publication-title: J. Chromatogr. B doi: 10.1016/S0378-4347(96)00205-8 – volume: 669 start-page: 265 year: 1995 ident: 10.1016/S0021-9673(98)00249-0_BIB11 publication-title: J. Chromatogr. B doi: 10.1016/0378-4347(95)00100-W – volume: 20 start-page: 1257 year: 1997 ident: 10.1016/S0021-9673(98)00249-0_BIB12 publication-title: J. Liq. Chromatogr. doi: 10.1080/10826079708010974 – volume: 20 start-page: 159 year: 1995 ident: 10.1016/S0021-9673(98)00249-0_BIB7 publication-title: J. Clin. Pharmacol. Ther. doi: 10.1111/j.1365-2710.1995.tb00642.x – volume: 10 start-page: 85 year: 1991 ident: 10.1016/S0021-9673(98)00249-0_BIB5 publication-title: Eur. J. Microb. Infect. Dis. doi: 10.1007/BF01964413 |
| SSID | ssj0017072 ssj0029838 |
| Score | 1.7011667 |
| Snippet | A rapid, accurate and sensitive liquid chromatographic assay with on-line solid-phase extraction for determination of meropenem in serum is described. Sample... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 249 |
| SubjectTerms | Antibiotics Chromatography, High Pressure Liquid Humans Indicators and Reagents Meropenem Solvents Spectrophotometry, Ultraviolet Thienamycins - blood Thienamycins - pharmacokinetics |
| Title | Determination of meropenem in serum by high-performance liquid chromatography with column switching |
| URI | https://dx.doi.org/10.1016/S0021-9673(98)00249-0 https://www.ncbi.nlm.nih.gov/pubmed/9691323 https://www.proquest.com/docview/80043365 |
| Volume | 812 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07TxwxELYQFEkTAQkKCQ8XKUhh8K69fpToAF1ygiIKCp3lp7ISt3chdwUNvx3PPu6UAiGlWq1X48fM7Hhsz3xG6EslbFAhClLawhNeMQp2kJHEnS14LIOVkO98fSPGt_z7XXW3gUZDLgyEVfa2v7PprbXuS856bp7N6xpyfPPfJiTTqsW9g3U75xJ0_fRpFeZRSCpXeFKlVqwzzRCXkEnXKT1ddW3hiVZf2xoJfWmyeskZbSelq230rvcm8XnX4R20EZtd9GY0XOL2HvmLIdwFBIBnCU8jbL83cYrrBmf9W06xe8SAWkzm6yQCfF__WdYB-98Ps-zT9rjWGHZtsQeDlmnzSxuI-QHdXl3-HI1Jf68C8UzQBUle-sCT9dIJnri0eUlWSEVdIcrsPeUPutCVo4kVzjIAsAmhLJNXurJCeMr20GYza-JHhHmZQmAyVdo67qLS3Gf_sLQ2Fik3Ue0jPjDQ-B50HO6-uDfr6LLMdwN8N1qZlu-G7qPTFdm8Q914jUAN0jH_qI_JM8NrpMeDNE0WDpyX2CbOln-NgmNSJvIg9johr_qihc6rePbp_1v9jN522Y2SUHaANhcPy3iY3ZuFO2r19whtnX-bjG_gOfnxa_IMSnT1Bw |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LTxsxELZQONBL1RcqFIoPPZSDi3ft9eOI0qJQICeQuFl-qiuRTZomB_49430k4oCQelyvxvbOeMcznpnPCH2rhA0qREFKW3jCK0azHmQkcWcLHstgZa53vpmKyR3_fV_d76DxUAuT0yp73d_p9FZb9y1nPTfPFnWda3zhbxOSadXi3oHfvssr8PZGaPf88moy3QQTJJUbSKlSK9Zp55yaANTbqp6ux7bxu1anbaeEvrRfvWSPtvvSxTv0tjco8Xk35_doJzYf0N54uMftI_I_h4yXLAM8T3gW8wl8E2e4bjAswfUMu0ecgYvJYltHgB_qv-s6YP9nOQeztoe2xvngFvus04AWHtpczE_o7uLX7XhC-qsViGeCrkjy0geerJdO8MSlBa-skIq6QpRgQMELXejK0cQKZ1nGsAmhLJNXurJCeMr20aiZN_EzwrxMITCZKm0dd1Fp7sFELK2NRYIhqgPEBwYa3-OO5-svHsw2wQz4bjLfjVam5buhB-jHhmzRAW-8RqAG6ZhnK8jA5vAa6ckgTQPCySET28T5-p9ROVLKBHzEfifkzVy00ODIs8P_H_UE7U1ub67N9eX06gt60xU7SkLZERqtlut4DNbOyn3tV_MTIHj2Gw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Determination+of+meropenem+in+serum+by+high-performance+liquid+chromatography+with+column+switching&rft.jtitle=Journal+of+Chromatography+A&rft.au=Bompadre%2C+S&rft.au=Ferrante%2C+L&rft.au=De+Martinis%2C+M&rft.au=Leone%2C+L&rft.date=1998-07-03&rft.pub=Elsevier+B.V&rft.issn=0021-9673&rft.volume=812&rft.issue=1&rft.spage=249&rft.epage=253&rft_id=info:doi/10.1016%2FS0021-9673%2898%2900249-0&rft.externalDocID=S0021967398002490 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9673&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9673&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9673&client=summon |