IL-6 Mutation Attenuates Liver Injury Caused by Aeromonas hydrophila Infection by Reducing Oxidative Stress in Zebrafish

• Published in: International journal of molecular sciences Vol. 24; no. 24; p. 17215
• Main Authors: Zhai, Wenya, Wang, Zhensheng, Ye, Canxun, Ke, Lan, Wang, Huanling, Liu, Hong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.12.2023
• Subjects: Aeromonas hydrophila - physiology; Animals; Apoptosis; Bacterial infections; Bacterial Infections - pathology; Chlorophyll; CRISPR; Cytochrome; Cytokine storm; Disease Models, Animal; Gene expression; Gram-Negative Bacterial Infections - genetics; Gram-Negative Bacterial Infections - microbiology; Infections; Inflammation; Interleukin-6 - genetics; Ischemia; Liver; Liver - pathology; Metabolism; Microorganisms; Mitochondria; Musculoskeletal system; Mutation; Oxidation-Reduction; Oxidative stress; Oxidative Stress - genetics; Reactive oxygen species; Zebrafish; Zebrafish - genetics; Zebrafish - microbiology; Zebrafish Proteins - metabolism; interleukin 6; CRISPR/Cas9; bacterial infection; transcriptome; reactive oxygen species

Interleukin-6 (IL-6), a pleiotropic cytokine, plays a crucial role in acute stress induced by bacterial infection and is strongly associated with reactive oxygen species (ROS) production. However, the role of IL-6 in the liver of fish after Aeromonas hydrophila infection remains unclear. Therefore,...