1000-plex antibody array proteomic screen uncovers PGRPS, Haptoglobin, Serpin A4 and Fibrinogen as potential stool biomarkers of pediatric inflammatory bowel disease

• Published in: Clinical immunology (Orlando, Fla.) Vol. 276; p. 110495
• Main Authors: Pereira, Ryan, Soomro, Sanam, Vanarsa, Kamala, Castillo, Jessica, Maruvada, Vinaika, Kugathasan, Subra, Mohan, Chandra
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2025
• Subjects: Adolescent; Biomarkers; Biomarkers - analysis; Biomarkers - metabolism; Child; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - metabolism; Crohn Disease - diagnosis; Crohn Disease - metabolism; Crohn's disease; Cross-Sectional Studies; Fecal proteomics; Feces - chemistry; Female; Fibrinogen - analysis; Fibrinogen - metabolism; Haptoglobins - analysis; Haptoglobins - metabolism; Humans; Inflammatory bowel disease; Inflammatory Bowel Diseases - diagnosis; Inflammatory Bowel Diseases - metabolism; Male; Proteomics - methods; Serpins - metabolism; Ulcerative colitis; Inflammatory bowel disease; Biomarkers; Fecal proteomics; Crohn's disease; Ulcerative colitis

Easy to obtain and in close proximity to the affected areas, fecal samples offer significant potential for the advancement of non-invasive diagnostic methods for inflammatory bowel disease (IBD). A cross-sectional antibody array-based proteomic screen of 1000 fecal protein biomarkers was conducted u...