Synthesis and conformational analysis of an α-d-mannopyranosyl-(1→2)-α-d-mannopyranosyl-(1→6)-α-d-mannopyranose mimic

A mimic of a (1→2),(1→6)-mannotrioside was synthesized by replacing the central mannose unit with an enantiomerically pure, conformationally stable trans-diaxial cyclohexanediol. The three-dimensional structure of the molecule was investigated by NMR spectroscopy supported by molecular modelling and...

Full description

Saved in:
Bibliographic Details
Published inCarbohydrate research Vol. 342; no. 12-13; pp. 1859 - 1868
Main Authors Mari, Silvia, Sánchez-Medina, Inmaculada, Mereghetti, Pierangelo, Belvisi, Laura, Jiménez-Barbero, Jesus, Bernardi, Anna
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 03.09.2007
Elsevier
Subjects
Biochemistry & Molecular Biology
Calorimetry
Carbohydrate Conformation
Carbohydrate mimics
Carbohydrate Sequence
Chemistry
Chemistry, Applied
Chemistry, Organic
Conformational analysis
Glycomimetics
Indicators and Reagents
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Mannosides - chemistry
Mannotrioside
Models, Molecular
Molecular Sequence Data
Physical Sciences
Science & Technology
Trisaccharides - chemical synthesis
Trisaccharides - chemistry
Glycomimetics
Mannotrioside
Carbohydrate mimics
Conformational analysis
mannotrioside
GLYCOSIDES
glycomimetics
carbohydrate mimics
OLIGOSACCHARIDES
conformational analysis
Online AccessGet full text

Cover

More Information
Summary:A mimic of a (1→2),(1→6)-mannotrioside was synthesized by replacing the central mannose unit with an enantiomerically pure, conformationally stable trans-diaxial cyclohexanediol. The three-dimensional structure of the molecule was investigated by NMR spectroscopy supported by molecular modelling and was compared to the known features of the natural mannotrioside.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2007.03.019