Lung specific stealth liposomes: stability, biodistribution and toxicity of liposomal antitubercular drugs in mice

• Published in: Biochimica et biophysica acta Vol. 1334; no. 2; pp. 161 - 172
• Main Authors: Deol, Parampal, Khuller, G.K
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.1997
• Subjects: Alanine Transaminase - blood; Alkaline Phosphatase - blood; Amylopectin; Animals; Antitubercular Agents - administration & dosage; Antitubercular Agents - therapeutic use; Antitubercular Agents - toxicity; Bilirubin - blood; Cholesterol; Drug Delivery Systems; Isoniazid - administration & dosage; Liposomes - chemistry; Liposomes - pharmacokinetics; Liver - metabolism; Lung - metabolism; Lung targeting; Macrophages - metabolism; Mice; Phosphatidylcholines; Rifampin - administration & dosage; Stealth liposome; Toxicity; Transaminases - blood; Tuberculosis - drug therapy; Tuberculosis - metabolism; Stealth liposome; Toxicity; Lung targeting

Liposomes with enhanced affinity towards lung tissue were prepared for the development of more effective chemotherapy against tuberculosis. Modification of surface of stealth liposomes by tagging O-stearylamylopectin (O-SAP) resulted in the increased affinity of these liposomes towards lung tissue o...