Bioluminescence imaging of fibroblast activation protein-alpha in vivo and human plasma with highly sensitive probe

• Published in: Analytical biochemistry Vol. 655; p. 114859
• Main Authors: Zhang, Ling, Ying, Weiwu, Sheng, Zhijia, Lv, Li, Gao, Jian, Xue, Yunsheng, Liu, Ling
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.10.2022
• Subjects: bioluminescence; Bioluminescence imaging; biomarkers; Fibroblast activation protein; fibroblasts; Gastric cancer; humans; metastasis; Probe; prognosis; signal-to-noise ratio; stomach neoplasms; Bioluminescence imaging; Probe; Gastric cancer; Fibroblast activation protein

Fibroblast activation protein-alpha (FAPα) has emerged as a biomarker of tumor stromal fibroblasts. FAP was overexpressed in stromal fibroblasts of human malignancies and positively correlated with the depth of tumor invasion, lymphatic metastasis, distant metastases, high TNM stage and poor prognos...