Immune Mechanisms in Murine Gammaherpesvirus-68 Infection

• Published in: Viral immunology Vol. 18; no. 3; pp. 445 - 456
• Main Authors: Stevenson, Philip G., Efstathiou, Stacey
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.09.2005
• Subjects: Animals; Antibodies, Viral; Epstein-Barr Virus Infections - immunology; Epstein-Barr Virus Infections - virology; Gammaherpesvirinae - genetics; Gammaherpesvirinae - immunology; Gammaherpesvirinae - pathogenicity; Genes, Viral; Herpesviridae Infections - immunology; Herpesviridae Infections - virology; Herpesvirus 8, Human - immunology; Herpesvirus 8, Human - pathogenicity; Humans; Mice; Models, Biological; Special Focus Section on Herpesvirus; T-Lymphocytes - immunology; Vaccination

The murine gamma-herpesvirus-68 (MHV-68) is a relative of the Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) that infects mice. All these gamma-herpesviruses are subject to immune control, but limit the impact of this control through immune evasion. Molecular evasio...