A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains - Martens, Erik; Leyssen, An; Van Aelst, Ilse; Fiten, Pierre; Piccard, Helene; Hu, Jialiang; Descamps, Francis J.; Van den Steen, Philippe E.; Proost, Paul; Van Damme, Jo; Liuzzi, Grazia Maria; Riccio, Paolo; et al. (Biochimica et biophysica acta, 2007)
Keywords: Amino Acid Sequence; Animals; Antibodies, Monoclonal - pharmacology; Binding Sites; Catalytic Domain; Cloning, Molecular; DNA, Complementary - genetics; Domain mapping; Enzyme Inhibitors - pharmacology; Fibronectins - chemistry; Fibronectins - metabolism; Gelatinase B; Genetic Variation; Humans; Hydrophilicity; Insecta; Matrix Metalloproteinase 9 - chemistry; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase Inhibitors; Matrix metalloproteinase-9; Molecular Sequence Data; Monoclonal antibody; Peptide Fragments - chemistry; Protease Inhibitors - pharmacology; Recombinant Proteins - antagonists & inhibitors; Recombinant Proteins - chemistry; Zinc - metabolism; Matrix metalloproteinase-9; MMP; ΔOG; SDS-PAGE; Hydrophilicity; ΔOGHem; Monoclonal antibody; EDTA; ΔHem; PVDF; Gelatinase B; Domain mapping