A FXYD5/TGF‑β/SMAD positive feedback loop drives epithelial‑to‑mesenchymal transition and promotes tumor growth and metastasis in ovarian cancer

• Published in: International journal of oncology Vol. 56; no. 1; pp. 301 - 314
• Main Authors: Bai, Yang, Li, Liang‑Dong, Li, Jun, Chen, Rui‑Fang, Yu, Hai‑Lin, Sun, He‑Fen, Wang, Jie‑Yu, Lu, Xin
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications UK Ltd 01.01.2020
• Subjects: Binding sites; Breast cancer; Feedback; Gynecology; Kinases; Laboratory animals; Metastasis; Obstetrics; Ovarian cancer; Penicillin; Protein expression; Proteins; Studies; Survival analysis; Tumors; Vectors (Biology); China

Epithelial ovarian cancer is aggressive and lacks effective prognostic indicators or therapeutic targets. In the present study, using immunohistochemistry and bioinformatics analysis on ovarian cancer tissue data from The Obstetrics and Gynecology Hospital of Fudan University and The Cancer Genome A...