Dictyostelium discoideum to human cells: Pharmacogenetic studies demonstrate a role for sphingolipids in chemoresistance

• Published in: Biochimica et biophysica acta Vol. 1760; no. 3; pp. 301 - 309
• Main Authors: Alexander, Stephen, Min, Junxia, Alexander, Hannah
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2006
• Subjects: Aldehyde-Lyases - biosynthesis; Aldehyde-Lyases - genetics; Animals; Cancer therapy; Cell Line; Cell Line, Tumor; Ceramide; Cisplatin; Cisplatin - pharmacology; Dictyostelium - drug effects; Dictyostelium - genetics; Drug Resistance - genetics; Drug Resistance - physiology; Extracellular Signal-Regulated MAP Kinases - metabolism; Glutathione; Glutathione - metabolism; Humans; JNK Mitogen-Activated Protein Kinases - metabolism; MAP kinase; p38 Mitogen-Activated Protein Kinases - metabolism; Pharmacogenetics; Phosphotransferases (Alcohol Group Acceptor) - genetics; Signal transduction modulator; Sphingolipids - physiology; Sphingosine 1-phosphate; Cancer therapy; Signal transduction modulator; Ceramide; MAP kinase; Cisplatin; Sphingosine 1-phosphate; Glutathione

Resistance to chemotherapy is a major obstacle for the treatment of cancer and a subject of extensive research. Numerous mechanisms of drug resistance have been proposed, and they differ for different drugs. Nevertheless, it is clear that our understanding of this important problem is still incomple...