Complex formation between endogenous toxin bilirubin and polyamidoamine dendrimers: A spectroscopic study

• Published in: Biochimica et biophysica acta Vol. 1760; no. 7; pp. 1021 - 1026
• Main Authors: Shcharbin, Dzmitry, Bryszewska, Maria
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2006
• Subjects: Absorption; Antioxidant; Antioxidants - chemistry; Bilirubin; Bilirubin - chemistry; Bilirubin - toxicity; Cations; Complex; Dendrimers; Detoxication; Dose-Response Relationship, Drug; Light; Molecular Structure; Photodestruction; Polyamidoamine dendrimer; Polyamines - chemistry; Polymers - chemistry; Solubility; Spectrometry, Fluorescence - methods; Surface Properties; Time Factors; Photodestruction; Solubility; Detoxication; Bilirubin; Antioxidant; Polyamidoamine dendrimer; Complex

The effects of 4th and 5th generation cationic, neutral and anionic polyamidoamine (PAMAM) dendrimers on bilirubin absorbance and fluorescence were studied. Cationic and neutral PAMAM dendrimers shifted the bilirubin absorption maximum from 435 to 442–455 nm, increased the peak absorbance 1.5-fold,...