Structural and Mechanistic Features of Phospholipases C: Effectors of Inositol Phospholipid-Mediated Signal Transduction

• Published in: Cellular Signalling Vol. 9; no. 5; pp. 329 - 336
• Main Authors: James, Stephen R., Downes, C.Peter
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier Inc 01.08.1997
• Subjects: effectors of inositol phospholipid-mediated; Enzyme Activation; Inositol; Isoenzymes; Phospholipases C; Protein Structure, Tertiary; Signal Transduction; Structure-Activity Relationship; Type C Phospholipases - chemistry; Type C Phospholipases - physiology; effectors of inositol phospholipid-mediated; PLC–phospholipase C; PH domain—pleckstrin homology domain; G protein—heterotrimeric GTP-binding protein; PtdCho—phosphatidylcholine; PtdInsP 2—phosphatidylinositol (4,5)-bisphosphate; Phospholipases C; PLCβT—turkey erythrocyte PLC; Signal transduction; PtdInsP—phosphatidylinositol 4-phosphate; DG— sn 1,2-diacylglycerol; PtdSer—phosphatidylserine; PITP—phosphatidylinositol transfer protein; InsP 3—inositol (1,4,5)-trisphosphate

The production of the intracellular second messengers inositol (1,4,5)-trisphosphate (InsP 3) and sn 1,2-diacylglycerol (DG) in response to a wide variety of extracellular primary messengers is achieved by an extended family of inositol phospholipid phosphodiesterases termed phospholipases C (PLC, E...