Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs - Qiu, Yongge; Li, Ding (Biochimica et biophysica acta, 2006)
Keywords: Animals; Cancer; Carboxy-Lyases - antagonists & inhibitors; Carboxy-Lyases - chemistry; Cardiovascular disease; Cardiovascular System - pathology; Cholesterol; Cholesterol - chemistry; Cloning, Molecular; Dose-Response Relationship, Drug; Fluorinated inhibitor; Fluorine - chemistry; Inhibitory Concentration 50; Kinetics; Mevalonate 5-diphosphate decarboxylase; Mevalonate kinase; Mevalonic Acid - chemistry; Models, Chemical; Phosphotransferases (Alcohol Group Acceptor) - chemistry; Rats; Substrate Specificity; PP; GGPP; MVK; GHMP; GPP; FPP; IPP; Fluorinated inhibitor; Cardiovascular disease; MDD; Cholesterol; PMK; TsCl; Mevalonate 5-diphosphate decarboxylase; Mevalonate kinase; HMG-CoA reductase; MVAPP; Cancer