The characterisation of three substituted zinc phthalocyanines of differing charge for use in photodynamic therapy. A comparative study of their aggregation and photosensitising ability in relation to mTHPC and polyhaematoporphyrin

• Published in: Journal of photochemistry and photobiology. B, Biology Vol. 45; no. 1; pp. 28 - 35
• Main Authors: Ball, Denise J., Wood, Simon R., Vernon, David I., Griffiths, John, Dubbelman, Tom M.A.R., Brown, Stanley B.
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 21.08.1998
• Subjects: Animals; Cattle; Erythrocytes - drug effects; Histidine; Humans; Indoles - chemistry; Indoles - pharmacology; Methanol; Molecular Structure; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Organophosphorus Compounds - chemistry; Organophosphorus Compounds - pharmacology; Oxidation-Reduction; Photochemotherapy; Photodynamic therapy; Photosensitizers; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Phthalocyanines; Porphyrins - chemistry; Porphyrins - pharmacology; Serum Albumin, Bovine - drug effects; Serum Albumin, Bovine - metabolism; Tryptophan; PBS; PDT; PPC; Photodynamic therapy; TGly; TDOPc; Photosensitizers; BSA; His; mTHPC; Pc; PEG; Trp; PHP; Hb; Phthalocyanines

Three substituted zinc (II) phthalocyanines (one anionic, one cationic and one hydrophobic) have been compared to two clinically used photosensitisers, 5,10,15,20-tetra( m-hydroxyphenyl)chlorin ( mTHPC) and polyhaematoporphyrin (PHP), as potential agents for photodynamic therapy (PDT). Oxygen-consum...