Analysis of ascomycin production enhanced by shikimic acid resistance and addition in Streptomyces hygroscopicus var. ascomyceticus

• Published in: Biochemical engineering journal Vol. 82; pp. 124 - 133
• Main Authors: Qi, Haishan, Zhao, Sumin, Wen, Jianping, Chen, Yunlin, Jia, Xiaoqiang
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.01.2014; Elsevier
• Subjects: Biological and medical sciences; Biosynthesis; Biotechnology; Enzyme activity; Fermentation; Fundamental and applied biological sciences. Psychology; Immunosuppressant; Methods. Procedures. Technologies; Microbial engineering. Fermentation and microbial culture technology; Optimization; Shikimic acid; Streptomyces hygroscopicus; Immunosuppressant; Biosynthesis; Enzyme activity; Fermentation; Shikimic acid; Optimization; Streptomyces hygroscopicus; Streptomycetaceae; Actinomycetales; Resistance; Enzymatic activity; Production; Bacteria; Actinomycetes

•A mutant SA68 was achieved by shikimic acid enduring selection model.•Ascomycin production reached the peak of 450mg/L with shikimic acid addition.•Pathways were identified providing key metabolites for higher ascomycin production. Shikimic acid resistance and addition to enhance immunosuppressant...