Epigenetics and atherosclerosis

• Published in: Biochimica et biophysica acta Vol. 1790; no. 9; pp. 886 - 891
• Main Authors: Turunen, Mikko P., Aavik, Einari, Ylä-Herttuala, Seppo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2009
• Subjects: Animals; Atherosclerosis; Atherosclerosis - genetics; DNA Methylation; Epigenesis, Genetic; Epigenetic; Histone code; Histones - metabolism; Homocysteinemia; Humans; Hypercholesterolemia; Hyperhomocysteinemia - genetics; Methylation; Hypercholesterolemia; Epigenetic; Homocysteinemia; Methylation; Atherosclerosis; Histone code

The contribution of epigenetic mechanisms to cardiovascular diseases remains poorly understood. Hypomethylation of genomic DNA is present in human atherosclerotic lesions and methylation changes also occur at the promoter level of several genes involved in the pathogenesis of atherosclerosis, such a...