Sensitivity of chondrocytes of growing cartilage to reactive oxygen species

• Published in: Biochimica et biophysica acta Vol. 1425; no. 1; pp. 103 - 111
• Main Authors: Fragonas, Emanuela, Pollesello, Piero, Mlinárik, Vladimir, Toffanin, Renato, Grando, Cristina, Godeas, Cristiana, Vittur, Franco
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 16.09.1998
• Subjects: Adenosine Triphosphate - metabolism; Animals; Cartilage - drug effects; Cartilage - growth & development; Cartilage - metabolism; Catalase - metabolism; Cells, Cultured; Chondrocytes - drug effects; Chondrocytes - metabolism; Glutathione Peroxidase - metabolism; Growing cartilage; Hydrogen Peroxide - metabolism; Hydrogen Peroxide - pharmacology; Hypertrophic chondrocyte; L-Lactate Dehydrogenase - metabolism; Lipid Metabolism; Magnetic Resonance Spectroscopy; Matrix vesicle; NMR; Osteogenesis; Reactive oxygen species; Reactive Oxygen Species - metabolism; Superoxide Dismutase - metabolism; Swine; Reactive oxygen species; Growing cartilage; LDH, lactate dehydrogenase; MUFA and PUFA, mono and polyunsaturated fatty acid chains; HX, hypoxanthine; XO, xanthine oxidase; SOD, superoxide dismutase; Matrix vesicle; PHGPx, phospholipid hydroperoxide glutathione peroxidase; NMR; Hypertrophic chondrocyte; HCs, RCs and ACs, hypertrophic, resting and articular chondrocytes; ROS, reactive oxygen species

Vascular invasion of calcified cartilage, during endochondral ossification, is initiated and sustained by invasive cells (endothelial cells and macrophages) which degrade the tissue by releasing lytic enzymes. Concurrently, reactive oxygen species (ROS) are also released by these cells and we hypoth...