Divergence of Noncoding Regulatory Elements Explains Gene–Phenotype Differences between Human and Mouse Orthologous Genes

• Published in: Molecular biology and evolution Vol. 35; no. 7; pp. 1653 - 1667
• Main Authors: Han, Seong Kyu, Kim, Donghyo, Lee, Heetak, Kim, Inhae, Kim, Sanguk
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.07.2018
• Subjects: Animal models; Annotations; Disease; Divergence; Evolutionary genetics; Genes; Genetic engineering; Genomes; Genotype & phenotype; Human subjects; Ontology; Organisms; Phenotypes; Regulatory sequences; Semantics; Similarity; Transcriptomics

Mice have been widely used as a model organism to investigate human gene-phenotype relationships based on a conjecture that orthologous genes generally perform similar functions and are associated with similar phenotypes. However, phenotypes associated with orthologous genes often turn out to be qui...