Spinal cord injury: Emerging beneficial role of reactive astrocytes’ migration
Spinal cord injury (SCI), despite considerable progress in palliative care, has currently no satisfying therapeutic leading to functional recovery. Inability of central nervous system severed axons to regenerate after injury is considered to originate from both limited intrinsic capabilities of neur...
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| Published in | The international journal of biochemistry & cell biology Vol. 40; no. 9; pp. 1649 - 1653 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier Ltd
2008
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| Abstract | Spinal cord injury (SCI), despite considerable progress in palliative care, has currently no satisfying therapeutic leading to functional recovery. Inability of central nervous system severed axons to regenerate after injury is considered to originate from both limited intrinsic capabilities of neurons and inhibitory effect of the local environment. Precisely, the so-called “glial scar” formed by reactive astrocytes in response to injury exerts a well-known axon-outgrowth inhibitory effect. However, recent studies revealed that role of reactive astrocytes after SCI is more complex. During the first weeks after injury, reactive astrocytes indeed protect the tissue and contribute to a spontaneous relative functional recovery. Compaction of the lesion center and seclusion of inflammatory cells by migrating reactive astrocytes seem to underlie this beneficial effect. Stimulation of reactive astrocytes migration in the sub-acute phase of SCI might thus represent a new approach to improve the functional outcome of patients. |
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| AbstractList | Spinal cord injury (SCI), despite considerable progress in palliative care, has currently no satisfying therapeutic leading to functional recovery. Inability of central nervous system severed axons to regenerate after injury is considered to originate from both limited intrinsic capabilities of neurons and inhibitory effect of the local environment. Precisely, the so-called “glial scar” formed by reactive astrocytes in response to injury exerts a well-known axon-outgrowth inhibitory effect. However, recent studies revealed that role of reactive astrocytes after SCI is more complex. During the first weeks after injury, reactive astrocytes indeed protect the tissue and contribute to a spontaneous relative functional recovery. Compaction of the lesion center and seclusion of inflammatory cells by migrating reactive astrocytes seem to underlie this beneficial effect. Stimulation of reactive astrocytes migration in the sub-acute phase of SCI might thus represent a new approach to improve the functional outcome of patients. |
| Author | Renault-Mihara, Francois Okada, Seiji Nakamura, Masaya Toyama, Yoshiaki Shibata, Shinsuke Okano, Hideyuki |
| Author_xml | – sequence: 1 givenname: Francois surname: Renault-Mihara fullname: Renault-Mihara, Francois organization: Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 2 givenname: Seiji surname: Okada fullname: Okada, Seiji organization: Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 3 givenname: Shinsuke surname: Shibata fullname: Shibata, Shinsuke organization: Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 4 givenname: Masaya surname: Nakamura fullname: Nakamura, Masaya organization: Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 5 givenname: Yoshiaki surname: Toyama fullname: Toyama, Yoshiaki organization: Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 6 givenname: Hideyuki surname: Okano fullname: Okano, Hideyuki email: hidokano@sc.itc.keio.ac.jp organization: Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18434236$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Astrocytes - cytology Astrocytes - pathology Cell Movement Humans Inflammation - complications Inflammation - pathology Migration Reactive astrocyte Spinal Cord Injuries - complications Spinal Cord Injuries - pathology Spinal cord injury Therapeutic |
| Title | Spinal cord injury: Emerging beneficial role of reactive astrocytes’ migration |
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