Oxidative DNA damage and augmentation of poly(ADP-ribose) polymerase/nuclear factor-kappa B signaling in patients with Type 2 diabetes and microangiopathy

• Published in: The international journal of biochemistry & cell biology Vol. 39; no. 9; pp. 1673 - 1684
• Main Authors: Adaikalakoteswari, Antonysunil, Rema, Mohan, Mohan, Viswanathan, Balasubramanyam, Muthuswamy
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 2007
• Subjects: Case-Control Studies; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetic Angiopathies - complications; Diabetic Angiopathies - metabolism; DNA - metabolism; DNA Damage; DNA-Formamidopyrimidine Glycosylase - metabolism; Female; Gene Expression Regulation; Humans; Male; Microangiopathy; Middle Aged; NF-kappa B - metabolism; NFκB; Oxidative DNA damage; Oxidative Stress; PARP; Poly(ADP-ribose) Polymerases - genetics; Poly(ADP-ribose) Polymerases - metabolism; Protein Binding; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction; Type 2 diabetes; Type 2 diabetes; PARP; NFκB; Microangiopathy; Oxidative DNA damage

Although oxidative stress and the subsequent DNA damage is one of the obligatory signals for poly(ADP-ribose) polymerase (PARP) activation and nuclear factor-kappa B (NFκB) alterations, these molecular aspects have not been collectively examined in epidemiological and clinical settings. Therefore, t...