Interaction of receptor-activity-modifying protein1 with tubulin

• Published in: Biochimica et biophysica acta Vol. 1770; no. 8; pp. 1145 - 1150
• Main Authors: Kunz, Thomas H., Mueller-Steiner, Sarah, Schwerdtfeger, Kerstin, Kleinert, Peter, Troxler, Heinz, Kelm, Jens M., Ittner, Lars M., Fischer, Jan A., Born, Walter
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2007
• Subjects: Antigens, Viral, Tumor - physiology; Axons - metabolism; Calcitonin gene-related peptide; Calcitonin receptor-like receptor; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Cloning, Molecular; Escherichia coli - genetics; Glutathione Transferase - metabolism; Humans; Intracellular Signaling Peptides and Proteins - chemistry; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS); Membrane Proteins - chemistry; Membrane Proteins - genetics; Membrane Proteins - metabolism; Microscopy, Confocal; Neuroblastoma - pathology; Neurons - metabolism; Precipitin Tests; Protein interaction; Protein Structure, Tertiary; Proteins - metabolism; Receptor Activity-Modifying Protein 1; Receptor Activity-Modifying Proteins; Receptor-activity-modifying protein; Recombinant Fusion Proteins - metabolism; Simian virus 40 - physiology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tubulin - chemistry; Tubulin - metabolism; Two-Hybrid System Techniques; β-tubulin; CTR; MALDI-TOF-MS; SDS; DTT; Receptor-activity-modifying protein; CLR; GST; PAGE; AM; β-tubulin; Calcitonin gene-related peptide; DMEM; RAMP; Protein interaction; CGRP; Calcitonin receptor-like receptor; Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS)

Receptor-activity-modifying protein (RAMP) 1 is an accessory protein of the G protein-coupled calcitonin receptor-like receptor (CLR). The CLR/RAMP1 heterodimer defines a receptor for the potent vasodilatory calcitonin gene-related peptide. A wider tissue distribution of RAMP1, as compared to that o...