Mitochondrial transcription in mammalian cells

• Published in: Frontiers in bioscience Vol. 22; no. 5; pp. 835 - 853
• Main Author: Alexeyev, Mikhail F
• Format: Journal Article
• Language: English
• Published: Singapore 2017
• Subjects: Adenosine Triphosphate - metabolism; Animals; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; DNA-Directed RNA Polymerases - metabolism; Humans; Mitochondria - metabolism; Mitochondrial Proteins - metabolism; Models, Biological; Promoter Regions, Genetic; RNA - genetics; RNA - metabolism; RNA Processing, Post-Transcriptional; RNA, Mitochondrial; Transcription Factors - metabolism; Transcription, Genetic; Transcriptome

As a consequence of recent discoveries of intimate involvement of mitochondria with key cellular processes, there has been a resurgence of interest in all aspects of mitochondrial biology, including the intricate mechanisms of mitochondrial DNA maintenance and expression. Despite four decades of res...