Baseline triglyceride-glucose, body mass index, end-diastolic internal diameter of the left atria and creatinine are independent predictors for pulmonary hypertension in coronary artery disease patients after percutaneous coronary intervention treatments

• Published in: Biomarkers in medicine Vol. 18; no. 23; pp. 1049 - 1059
• Main Authors: Xie, Li, Fu, Shilin, Xu, Yuzheng, Ran, Litong, Luo, Jing, Rao, Rongsheng, Chen, Jianfei, Bian, Shi-Zhu, Qian, Dehui
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 2024
• Subjects: Aged; Biomarkers - blood; Blood Glucose - analysis; Blood Glucose - metabolism; Body Mass Index; Coronary Artery Disease - blood; Coronary Artery Disease - surgery; Creatinine - blood; Echocardiography; Female; Heart Atria - diagnostic imaging; Heart Atria - pathology; Heart Atria - physiopathology; Humans; Hypertension, Pulmonary - blood; Hypertension, Pulmonary - etiology; Male; Middle Aged; Percutaneous Coronary Intervention - adverse effects; Triglycerides - blood; coronary artery disease; percutaneous coronary intervention; pulmonary hypertension; TyG index; echocardiography
• ISSN: 1752-0363; 1752-0371; 1752-0371
• DOI: 10.1080/17520363.2024.2422807

To identify the predictive role of triglyceride-glucose (TyG) index in pulmonary hypertension (PH) in coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI) treatment. Blood biomarkers have been measured at the cross-section of entrance. The baseline and followed-up echocardiography have been performed at both cross-sections. The incidence of PH was 8.91%. The baseline myoglobin (MYO), was significantly higher among PH patients (  < 0.001). In the univariate regression, body mass index (BMI  = 0.020), left atria end-diastolic internal diameter (LAD,  = 0.083), creatinine (Cr,  = 0.005), triglyceride (TG,  < 0.001), high-density lipoprotein cholesterol (HDL-C,  = 0.056) and TyG index (  = 0.002) were potential predictors for PH. Finally, the adjusted COX regression indicated that BMI (  = 0.001), LAD (  = 0.030), Cr(  = 0.005) and TyG index (  = 0.002) were independent predictors of the onset of PH. Baseline TyG index, BMI, LAD, Cr level were independent predictors for PH in CAD patients after PCI treatment.