Trimethoprim-sulfamethoxazole compared with vancomycin for the treatment of Staphylococcus aureus infection

• Published in: Annals of internal medicine Vol. 117; no. 5; p. 390
• Main Authors: Markowitz, N, Quinn, E L, Saravolatz, L D
• Format: Journal Article
• Language: English
• Published: United States 01.09.1992
• Subjects: Adult; Bacteriophage Typing; Double-Blind Method; Female; Humans; Male; Methicillin Resistance; Microbial Sensitivity Tests; Prospective Studies; Staphylococcal Infections - drug therapy; Staphylococcal Infections - etiology; Substance Abuse, Intravenous - complications; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination - adverse effects; Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use; Vancomycin - adverse effects; Vancomycin - therapeutic use

To compare trimethoprim-sulfamethoxazole (TMP-SMZ) and vancomycin regarding efficacy and safety in the therapy of serious Staphylococcus aureus infections. Randomized, double-blind comparative trial. A tertiary-care hospital. One hundred and one intravenous drug users hospitalized with S. aureus inf...