Organophosphate toxicity patterns: A new approach for assessing organophosphate neurotoxicity

• Published in: Journal of hazardous materials Vol. 470; p. 134236
• Main Authors: Karaboga, Sinan, Severac, Florence, Collins, Eva-Maria S., Stab, Aurélien, Davis, Audrey, Souchet, Michel, Hervé, Grégoire
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.05.2024
• Subjects: Cholinesterases; Computational modeling; New Approach Method (NAM); Planarians; Quantitative Structure Activity Relationship (QSAR); Planarians; New Approach Method (NAM); Computational modeling; Quantitative Structure Activity Relationship (QSAR); Cholinesterases

Organophosphorus compounds or organophosphates (OPs) are widely used as flame retardants, plasticizers, lubricants and pesticides. This contributes to their ubiquitous presence in the environment and to the risk of human exposure. The persistence of OPs and their bioaccumulative characteristics rais...