Amino Acid Catabolism in Multiple Sclerosis Affects Immune Homeostasis

• Published in: The Journal of immunology (1950) Vol. 198; no. 5; pp. 1900 - 1909
• Main Authors: Negrotto, Laura, Correale, Jorge
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 01.03.2017
• Subjects: Adult; Amino acids; Arginase; Arginase - genetics; Arginine - metabolism; Autoimmune diseases; Cell proliferation; Chemoreception; CTLA-4 protein; Cytokines; Cytokines - immunology; Cytokines - secretion; Dioxygenase; Enzymes; Exploration; Female; Homeostasis; Humans; Immune system; Immunoregulation; Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics; Kinases; Lymphocytes T; Male; Multiple sclerosis; Multiple Sclerosis - immunology; Multiple Sclerosis - metabolism; Multiple Sclerosis - therapy; Myelin; Myelin basic protein; Neurological diseases; Nitric Oxide Synthase Type II - genetics; Protein-Serine-Threonine Kinases - genetics; Protein-serine/threonine kinase; Rapamycin; Sclerosis; Secretion; T-Lymphocytes, Regulatory - immunology; TLR9 protein; Toll-like receptors; Tryptophan - metabolism; Tryptophan Oxygenase - genetics; Young Adult

Amino acid catabolism has been implicated in immunoregulatory mechanisms present in several diseases, including autoimmune disorders. Our aims were to assess expression and activity of enzymes involved in Trp and Arg catabolism, as well as to investigate amino acid catabolism effects on the immune s...