Association between renin–angiotensin–aldosterone system blockade and future osteoporotic fracture risk in hypertensive population A population-based cohort study in Taiwan

• Published in: Medicine (Baltimore) Vol. 96; no. 46; p. e8331
• Main Authors: Chen, Chang-I., Yeh, Jong-Shiuan, Tsao, Nai-Wen, Lin, Fen-Yen, Shih, Chun-Ming, Chiang, Kuang-Hsing, Kao, Yung-Ta, Fang, Yu-Ann, Tsai, Lung-Wen, Liu, Wen-Chi, Nakagami, Hironori, Morishita, Ryuichi, Kuo, Yi-Jie, Huang, Chun-Yao
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health 01.11.2017
• Subjects: Aged; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Cohort Studies; Female; Humans; Hypertension - drug therapy; Male; Middle Aged; Observational Study; Osteoporotic Fractures - epidemiology; Osteoporotic Fractures - prevention & control; Renin-Angiotensin System - drug effects; Taiwan - epidemiology

Tissue renin-angiotensin-aldosterone system (RAAS) activation in sites of osteoporosis had been demonstrated in animal studies; however, the possibility of RAAS blockade to prevent future osteoporotic fracture had rarely been verified in clinical studies. We Used the Taiwan Longitudinal Health insur...