Gene Therapy for Ischemic Cardiovascular Diseases: Some Lessons Learned from the First Clinical Trials
Stimulation of angiogenesis, arteriogenesis, and lymphangiogenesis (i.e., therapeutic vascular growth) is a new concept for the treatment of ischemic cardiovascular diseases. A wealth of information is already available about the mechanisms and mediators of angiogenesis and arteriogenesis, which has...
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| Published in | Trends in cardiovascular medicine Vol. 14; no. 8; pp. 295 - 300 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.11.2004
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Stimulation of angiogenesis, arteriogenesis, and lymphangiogenesis (i.e., therapeutic vascular growth) is a new concept for the treatment of ischemic cardiovascular diseases. A wealth of information is already available about the mechanisms and mediators of angiogenesis and arteriogenesis, which has led to the first randomized, controlled, phase II/III trials with recombinant growth factors or their genes. Even though end points predefined in the study protocols have been positive in several trials, it is still evident that the trials have not produced any clearly meaningful clinical benefits for the patients. This review addresses same questions and concepts related to the gene therapy-based applications of therapeutic vascular growth. |
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| AbstractList | Stimulation of angiogenesis, arteriogenesis, and lymphangiogenesis (i.e., therapeutic vascular growth) is a new concept for the treatment of ischemic cardiovascular diseases. A wealth of information is already available about the mechanisms and mediators of angiogenesis and arteriogenesis, which has led to the first randomized, controlled, phase II/III trials with recombinant growth factors or their genes. Even though end points predefined in the study protocols have been positive in several trials, it is still evident that the trials have not produced any clearly meaningful clinical benefits for the patients. This review addresses same questions and concepts related to the gene therapy-based applications of therapeutic vascular growth. |
| Author | Markkanen, Johanna E. Rissanen, Tuomas T. Ylä-Herttuala, Seppo |
| Author_xml | – sequence: 1 givenname: Seppo surname: Ylä-Herttuala fullname: Ylä-Herttuala, Seppo email: seppo.ylaherttuala@uku.fi – sequence: 2 givenname: Johanna E. surname: Markkanen fullname: Markkanen, Johanna E. – sequence: 3 givenname: Tuomas T. surname: Rissanen fullname: Rissanen, Tuomas T. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15596105$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Angiogenesis Angiogenesis Inducing Agents - therapeutic use Animals Cardiovascular disease Clinical trials Clinical Trials as Topic Drug dosages Efficiency Genetic Therapy Humans Ischemia - therapy Models, Animal Neovascularization, Physiologic - drug effects Pharmacology Recombinant Proteins - genetics Recombinant Proteins - therapeutic use Studies Vascular endothelial growth factor Vascular Endothelial Growth Factors - genetics Vascular Endothelial Growth Factors - therapeutic use Veins & arteries |
| Title | Gene Therapy for Ischemic Cardiovascular Diseases: Some Lessons Learned from the First Clinical Trials |
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