Regulation of hyaluronan and versican deposition by growth factors in fibrosarcoma cell lines

• Published in: Biochimica et biophysica acta Vol. 1780; no. 2; pp. 194 - 202
• Main Authors: Berdiaki, A., Zafiropoulos, A., Fthenou, E., Katonis, P., Tsatsakis, A., Karamanos, N.K., Tzanakakis, G.N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2008
• Subjects: Basic fibroblast growth factor; Cell Line, Tumor; Fibroblast Growth Factor 2 - metabolism; Fibroblast Growth Factor 2 - pharmacology; Fibrosarcoma; Fibrosarcoma - metabolism; Glucuronosyltransferase - analysis; Glucuronosyltransferase - metabolism; Humans; Hyaluronan; Hyaluronan Synthases; Hyaluronic Acid - biosynthesis; Platelet derived growth factor BB; Platelet-Derived Growth Factor - metabolism; Platelet-Derived Growth Factor - pharmacology; Protein Isoforms - metabolism; Proto-Oncogene Proteins c-sis; Transforming growth factor B2; Transforming Growth Factor beta2 - metabolism; Transforming Growth Factor beta2 - pharmacology; Versican; Versicans - biosynthesis; Hyaluronan; Transforming growth factor B2; Hyaluronan synthases; Fibrosarcoma; Basic fibroblast growth factor; Platelet derived growth factor BB; Versican

Versican, a large chondroitin sulphate proteoglycan and hyaluronan (HA), a non-sulphated glycosaminoglycan are major constituents of the pericellular matrix. In many neoplastic tissues, changes in the expression of versican and HA affect tumour progression. Here, we analyse the synthesis of versican...