Regulation of brain capillary endothelial thrombomodulin mRNA expression

• Published in: Stroke (1970) Vol. 27; no. 12; pp. 2304 - 2311
• Main Authors: Tran, N D, Wong, V L, Schreiber, S S, Bready, J V, Fisher, M
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.12.1996
• Subjects: Animals; Astrocytes - physiology; Blood-Brain Barrier - physiology; Brain - blood supply; Capillaries - cytology; Capillaries - metabolism; Cattle; Cells, Cultured; Coculture Techniques; Gene Expression Regulation; In Situ Hybridization; Mice; Polymerase Chain Reaction; RNA, Messenger - biosynthesis; Thrombomodulin - biosynthesis; Thrombomodulin - genetics

Endothelial cells regulate hemostasis in part via expression of thrombomodulin, a potent anticoagulant protein. The purpose of this study was to analyze brain capillary endothelial cell expression of thrombomodulin mRNA. Bovine brain capillary endothelial cells were grown in a blood-brain barrier mo...