Molecular mimicry-driven autoimmunity in chronic rhinosinusitis with nasal polyps

• Published in: Journal of allergy and clinical immunology Vol. 155; no. 5; pp. 1521 - 1535
• Main Authors: Asamori, Tomoaki, Katoh, Hiroto, Takata, Mikiya, Komura, Daisuke, Kakiuchi, Miwako, Hashimoto, Itaru, Sakurai, Madoka, Yamamoto, Asami, Tsutsumi, Takeshi, Asakage, Takahiro, Ota, Yasushi, Ishikawa, Shumpei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2025
• Subjects: Adult; Autoantibodies - immunology; Autoantigens - immunology; Autoimmunity; B-Lymphocytes - immunology; Chronic Disease; CRSwNP; Female; Humans; humoral antigen; immunoglobulin; Male; microbial immunity; Middle Aged; molecular mimicry; Molecular Mimicry - immunology; Nasal Polyps - immunology; repertoire sequencing; Rhinitis - immunology; Rhinosinusitis; Sinusitis - immunology; NP; CSR; scBCR; immunoglobulin; ESS; CRS; IP; CRSwNP; HRSV; CMV; BCR; molecular mimicry; autoimmunity; repertoire sequencing; microbial immunity; SHM; humoral antigen; TLR; IF; dsDNA

[Display omitted] The pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) remains a subject of discussion. Although both microbial infection and autoimmunity have been proposed as potential contributors to CRSwNP pathobiology, their respective roles and intricate interactions in diseas...