Cdc48 and Ubx1 participate in a pathway associated with the inner nuclear membrane that governs Asi1 degradation

• Published in: Journal of cell science Vol. 129; no. 20; pp. 3770 - 3780
• Main Authors: Pantazopoulou, Marina, Boban, Mirta, Foisner, Roland, Ljungdahl, Per O.
• Format: Journal Article
• Language: English
• Published: England 15.10.2016
• Subjects: Adenosine Triphosphatases - metabolism; Cell Cycle Proteins - metabolism; Cell Nucleus - metabolism; Endoplasmic Reticulum-Associated Degradation; Genetic Testing; INMAD; Inner nuclear-membrane-associated degradation; Intracellular Signaling Peptides and Proteins - metabolism; Membrane dislocation; Membrane Proteins - metabolism; Models, Biological; Nuclear envelope; Nuclear Envelope - metabolism; Proteasome; Proteasome Endopeptidase Complex - metabolism; Proteolysis; Saccharomyces cerevisiae; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - metabolism; Signal Transduction; Ubiquitin; Ubiquitin - metabolism; Ubiquitin-Protein Ligases - metabolism; Valosin Containing Protein; Ubiquitin; Membrane dislocation; INMAD; Inner-nuclear-membrane-associated degradation; Nuclear envelope; Saccharomyces cerevisiae; Proteasome

The nuclear envelope is a barrier comprising outer and inner membranes that separate the cytoplasm from the nucleoplasm. The two membranes have different physical characteristics and protein compositions. The processes governing the stability of inner nuclear membrane (INM) proteins are not well cha...