Expression of ligand-induced binding sites on glycoprotein IIb/IIIa complexes and the effect of various inhibitors

• Published in: The American heart journal Vol. 135; no. 5; pp. S179 - S183
• Main Authors: Jennings, Lisa K., White, Melanie M.
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.05.1998
• Subjects: Antibodies, Monoclonal - immunology; Binding Sites - physiology; Humans; Ligands; Molecular Conformation; Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex - chemistry; Platelet Glycoprotein GPIIb-IIIa Complex - metabolism

Glycoprotein (GP) IIb/IIIa is a therapeutic target for the blockade of platelet aggregation during acute coronary syndromes. Peptides, peptidomimetics, and antibodies are generated that competitively block the binding of fibrinogen or von Willebrand factor to the activated GPIIb/IIIa complex. Bindin...