Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span

• Published in: Journal of medicinal food Vol. 23; no. 11; p. 1129
• Main Author: Zemel, Michael B
• Format: Journal Article
• Language: English
• Published: United States 01.11.2020
• Subjects: AMP-Activated Protein Kinases - metabolism; Animals; Humans; Insulin Resistance; Leucine - administration & dosage; Leucine - pharmacology; Longevity; Mice, Obese; Prediabetic State; Resveratrol - administration & dosage; Resveratrol - pharmacology; Sirtuin 1 - metabolism; Stilbenes - pharmacology; leucine; AMPK; Sirt1; metabolism; resveratrol

Sirt1 and 5' adenosine monophosphate-activated protein kinase (AMPK) are energy-sensing systems that work cooperatively and regulate mitochondrial biogenesis and fuel metabolism, and mediate, in part, the salutary effects of caloric restriction on lifespan and healthspan. We have shown that leu...