Growth Factor Receptor Bound Protein 2–Associated Binder 2, a Scaffolding Adaptor Protein, Negatively Regulates Host Immunity against Tuberculosis

• Published in: American journal of respiratory cell and molecular biology Vol. 51; no. 4; pp. 575 - 585
• Main Authors: Hu, Shizong, Zhang, Yan, Yu, Yang, Jin, Dongdong, Zhang, Xue, Gu, Shuxiang, Jia, Hongyan, Chen, Xinchun, Zhang, Zongde, Jin, Qi, Ke, Yuehai, Liu, Haiying
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.10.2014
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Bacterial Load; Case-Control Studies; Chemokines; Cytokines; Disease; Disease Models, Animal; GATA3 Transcription Factor - metabolism; Glycerol; Host-Pathogen Interactions; Humans; Immune system; Immunity, Cellular; Infections; Inflammation Mediators - metabolism; Lung - immunology; Lung - metabolism; Lung - pathology; Lung - virology; Lymphocytes; Mice; Mice, Knockout; Mycobacterium tuberculosis; Mycobacterium tuberculosis - immunology; Mycobacterium tuberculosis - pathogenicity; Phosphoproteins - deficiency; Phosphoproteins - genetics; Phosphoproteins - metabolism; Proteins; Regulation; RNA, Messenger - metabolism; Rodents; Software; Studies; T cell receptors; TCF Transcription Factors - metabolism; Time Factors; Tuberculosis; Tuberculosis, Pulmonary - genetics; Tuberculosis, Pulmonary - immunology; Tuberculosis, Pulmonary - metabolism; Tuberculosis, Pulmonary - pathology; Tuberculosis, Pulmonary - prevention & control; Tuberculosis, Pulmonary - virology; cytokine; pulmonary tuberculosis; growth factor receptor bound protein 2–associated binder 2; CFU; Mycobacterium tuberculosis

Cell-mediated immunity is indispensable for host protection against tuberculosis (TB). Growth factor receptor bound protein 2-associated binder (Gab) 2, a scaffolding adaptor protein, negatively regulates signaling pathways critical for T cell-mediated immunity. We sought to investigate the clinical...