Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

• Published in: Biochimica et biophysica acta Vol. 1780; no. 11; pp. 1236 - 1248
• Main Authors: Krauth-Siegel, R. Luise, Comini, Marcelo A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2008
• Subjects: Animals; DNA, Kinetoplast - biosynthesis; Glutaredoxin; Glutathione - analogs & derivatives; Glutathione - chemistry; Glutathione - metabolism; Glutathione peroxidase; Glutathionylation; Oxidation-Reduction; Parasites - metabolism; Peroxiredoxin; Spermidine - analogs & derivatives; Spermidine - chemistry; Spermidine - metabolism; Sulfhydryl Compounds - metabolism; Thiol metabolism; Thioredoxin; Trypanosoma; Trypanosoma - metabolism; Trypanothione; Tryparedoxin; Peroxiredoxin; Glutathione peroxidase; Trypanosoma; Tryparedoxin; Thiol metabolism; Glutaredoxin; Glutathionylation; Thioredoxin; Trypanothione

Trypanosomes and leishmania, the causative agents of several tropical diseases, possess a unique redox metabolism which is based on trypanothione. The bis(glutathionyl)spermidine is the central thiol that delivers electrons for the synthesis of DNA precursors, the detoxification of hydroperoxides an...