REFERENCE VALUES FOR LEISHMANIA INFANTUM PARASITEMIA IN DIFFERENT CLINICAL PRESENTATIONS: QUANTITATIVE POLYMERASE CHAIN REACTION FOR THERAPEUTIC MONITORING AND PATIENT FOLLOW-UP

• Published in: The American journal of tropical medicine and hygiene Vol. 75; no. 5; pp. 858 - 863
• Main Authors: MARY, CHARLES, FARAUT, FRANCOISE, DROGOUL, MARIE-PIERRE, XERIDAT, BERNARD, SCHLEINITZ, NICOLAS, CUISENIER, BERNADETTE, DUMON, HENRI
• Format: Journal Article
• Language: English
• Published: United States ASTMH 01.11.2006
• Subjects: Amphotericin B - therapeutic use; Animals; DNA, Protozoan - analysis; DNA, Protozoan - blood; Follow-Up Studies; Leishmania infantum; Leishmania infantum - genetics; Leishmania infantum - isolation & purification; Leishmaniasis, Visceral - diagnosis; Leishmaniasis, Visceral - drug therapy; Leishmaniasis, Visceral - parasitology; Parasitemia - blood; Parasitemia - diagnosis; Parasitemia - epidemiology; Parasitemia - parasitology; Polymerase Chain Reaction - methods; Polymerase Chain Reaction - veterinary; Recurrence; Reference Values; Sensitivity and Specificity

Quantification of Leishmania infantum DNA in blood samples by an ultrasensitive quantitative polymerase chain reaction (QPCR) detected parasitemias in different clinical presentations. We observed a large range of parasitemias, more than 9 log values, and could determine the threshold between asympt...