The Concentration of IgG in the Serum Is a Major Determinant of Fc-Dependent Reticuloendothelial Function

• Published in: Blood Vol. 66; no. 3; pp. 490 - 495
• Main Authors: Kelton, John G., Singer, Joel, Rodger, Claudia, Gauldie, Jack, Horsewood, Peter, Dent, Peter
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.09.1985; The Americain Society of Hematology
• Subjects: Agammaglobulinemia - blood; Antibodies, Antinuclear - metabolism; Antigen-Antibody Complex - metabolism; Biological and medical sciences; Female; Humans; Hypergammaglobulinemia - blood; Immunodeficiencies. Immunoglobulinopathies; Immunoglobulin G - metabolism; Immunoglobulinopathies; Immunoglobulins - administration & dosage; Immunopathology; Isoantibodies - administration & dosage; Male; Medical sciences; Mononuclear Phagocyte System - metabolism; Receptors, Fc - physiology; Rh Isoimmunization - blood; Rh-Hr Blood-Group System - immunology; Rho(D) Immune Globulin; Competition; Human; Immunoglobulinemia; Immunopathology; Immunoglobulins; Agammaglobulinemia; IgG; Clearance; Regulation(control); Fc-Fragment; Immunoglobulinopathy; Content; Serum

Defective Fc receptor-specific reticuloendothelial (RE) function has been reported in certain patients with a variety of immunologic and nonimmunologic diseases. The mechanism responsible for the impaired RE function is uncertain, but it could be caused by immune complexes that are present in many o...