IgA With altered carbohydrate structure as a tumor-associated marker in serum of cancer patients

• Published in: Journal of clinical laboratory analysis Vol. 2; no. 4; pp. 225 - 234
• Main Authors: Henslee, Jerry G., Rittenhouse, Harry G., Matias, Matthew S., Michael Hass, G., Schenck, Jay R., Tomita, Joseph T.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 1988
• Subjects: CEA; colon cancer; IgA1; lectin-enzyme immunoassay; O-glycosidic linkages; peanut agglutinin

Serum IgA1 contains O‐linked carbohydrate structures, whereas other immuno‐globulins contain only N‐linked structures. An assay was developed which detects IgA1 by measuring the DGalβ(1–3) DGalNAc structures O‐linked to the IgA1 hinge region. Fifty percent of the serum specimens from cancer patients...