Procoagulant changes in fibrin clot structure in patients with cirrhosis are associated with oxidative modifications of fibrinogen

• Published in: Journal of thrombosis and haemostasis Vol. 14; no. 5; pp. 1054 - 1066
• Main Authors: Hugenholtz, G. C. G., Macrae, F., Adelmeijer, J., Dulfer, S., Porte, R. J., Lisman, T., Ariëns, R. A. S.
• Format: Journal Article
• Language: English
• Published: England 01.05.2016
• Subjects: Adult; Blood Coagulation; Blood Coagulation Tests; Coagulants - chemistry; Factor XIII - chemistry; Female; Fibrin - chemistry; fibrinogen; Fibrinogen - chemistry; Fibrosis - blood; Healthy Volunteers; Hemostasis; Hemostatics; Humans; liver cirrhosis; Male; Malondialdehyde - blood; Microscopy, Confocal; Microscopy, Electron, Scanning; Middle Aged; oxidative stress; Oxygen - chemistry; Permeability; thrombosis; Thrombosis - blood; thrombosis; hemostasis; fibrinogen; liver cirrhosis; oxidative stress

Essentials Patients with cirrhosis have hemostatic changes, which may contribute to a risk of thrombosis. This in vitro study compares clot formation and structure between patients and healthy subjects. Clot formation is delayed in patients; ultimately, however, clot permeability is decreased. The t...